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Papers of the Week
Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol.
Authors
Abstract
Cannabinoids represent a promising therapeutic avenue for chronic pain, however clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition of voltage-gated calcium channels is one mechanism through which cannabinoids may produce analgesia. We hypothesized that cannabinoids and cannabinoid receptor agonists target different types of voltage gated calcium channels through distinct mechanisms.