News

Jul 22 2020
Analgesia From General Anesthetics: A “Pain-Off” Switch in the Central Amygdala
Isoflurane and ketamine engage a pain-suppression circuit controlled by GABAergic neurons in the CeA
news Research
Jul 16 2020
A Mislabeled Line? Well-Known Itch Afferents Can Code Pain, Too
Whether MrgprA3 neurons drive itch or pain depends on how the cells are activated; distinct spinal cord pathways underlie each sensation
news Research
Jun 24 2020
A 10-Year Anniversary: Reflecting on the Declaration of Montreal
One decade ago, pain stakeholders from around the globe called for the world to recognize that access to pain management is a fundamental human right. How has the Declaration of Montreal influenced pain research and treatment in the years since?
news Research
Jun 18 2020
Does Dendritic Spine Plasticity Contribute to Pain? The Evidence Is Mushrooming
Two-photon imaging study links changes in the structure of dorsal horn dendritic spines to neuropathic pain, in a mouse spared nerve injury model
news Drug Development | Research

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Postdoctoral Research Positions in Neuroimaging Pain Research
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Jul 30 2020
Building an Evidence Base in Chiropractic Medicine: A Conversation With Petra Schweinhardt
Catherine Paré

Editor’s note: Petra Schweinhardt, MD PhD, is the head of research of the Department of Chiropractic Medicine at the Balgrist...

Interview
Jul 27 2020
PRF Seminar – Preclinical Migraine Models and the Identification of Sexually Dimorphic (and Monomorphic) Mechanisms
PRF Team

Editor’s note: This is the 13th in a series of weekly PRF seminars designed to help keep the pain research community connected during...

Webinar

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Recent Comments

Jul 23 2020
By: John Quintner
About: A New Proposed Definition of Pain
Introducing the word "resembling" in relation to "the unpleasant sensory...
News
Jul 16 2020
By: PRF Executive Editor
About: A New Proposed Definition of Pain
The revised definition of pain has now been published in PAIN, along with...
News
May 15 2020
By: Johan Vlaeyen
About: Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art.
You may wish to have a look at some more recent updates of this paper: [1...
Paper
Mar 06 2020
By: Ashlie Reker
About: The Operant Plantar Thermal Assay: A Novel Device for Assessing Thermal Pain Tolerance in Mice.
Editor's note: this comment is co-authored by Ashlie Reker and Steve...
Paper
Feb 24 2020
By: Steve Negus
About: The Operant Plantar Thermal Assay: A Novel Device for Assessing Thermal Pain Tolerance in Mice.
An unexpected finding in this study was that CCI increased rather than...
Paper
Dec 18 2019
By: PRF Executive Editor
About: Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
Editor's note: This was the most popular paper on PRF over the past...
Paper
Dec 18 2019
By: PRF Executive Editor
About: Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
Editor's Note: This paper was the most popular paper on PRF in 2019....
Paper
Sep 30 2019
By: Mamata Tamrakar
About: A New Proposed Definition of Pain
The pain threshold for each individual differs, which makes it more...
News
Sep 30 2019
By: John Quintner
About: A New Proposed Definition of Pain
In his introductory remarks, although Murat Aydede1 mentions the...
News
Sep 30 2019
By: Marc Mathys
About: A Causal Role for Long-Term Potentiation in Chronic Pain
Wonderful paper. Have the researchers found any evidence for differences...
News
Sep 14 2019
By: Murat Aydede
About: A New Proposed Definition of Pain
The news article states: "But one thing most agree on is that the...
News
Jul 13 2019
By: Howard Fields
About: Magnitude, response, and psychological determinants of placebo effects in chronic low-back pain: a randomised, double-blinded, controlled trial.
In this elegant study, the authors compare lidocaine injection of the...
Paper
Jun 03 2019
By: Howard Fields
About: Pain Management Best Practices Inter-Agency Task Force Report: Updates, Gaps, Inconsistencies, and Recommendations. Published May 9, 2019 by the US Department of Health.
Because of the epidemic of opioid overdose and the potential contribution...
Paper
Apr 01 2019
By: John Wood
About: Pain-in-a-Dish Expands the Nav1.7 Research Menu
In the accompanying paper, Bennett, Serra, and Tracey make an important...
News
Mar 29 2019
By: Howard Fields
About: Core Outcome Measures in Preclinical Assessment of Candidate Analgesics.
Negus and colleagues have provided a useful in-depth review of the broad...
Paper
Mar 14 2019
By: Markus Ploner
About: Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception.
The study by Tan et al. represents a major step forward in understanding...
Paper
Jan 17 2019
By: Howard Fields
About: Hedonic drinking engages a supra-spinal inhibition of thermal nociception in adult rats.
This is an excellent paper investigating the analgesic effect of sucrose...
Paper
Nov 23 2018
By: Hiroshi Ueda
About: Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study.
This study seems to provide the first clinical evidence to support basic...
Paper
Oct 05 2018
By: Halina Machelska
About: Kappa Opioid Receptor Distribution and Function in Primary Afferents.
This is an interesting study confirming analgesic effects mediated by...
Paper
Aug 20 2018
By: Ru-Rong Ji
About: MicroRNA-30c-5p modulates neuropathic pain in rodents.
This is an interesting study with translational potential. The authors...
Paper
Aug 13 2018
By: Seena Ajit
About: miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus.
The conventional role of microRNAs (miRNAs) is to regulate gene expression...
Paper
Jun 18 2018
By: PRF Executive Editor
About: NIH Announces HEAL Initiative to Combat Opioid Crisis
Since publication of this news story, JAMA has published a Viewpoint by...
News
May 25 2018
By: Howard Fields
About: Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
Drs. Yezierski and Hansson have provided a timely, readable, scholarly and...
Paper
May 24 2018
By: Reza Sharif-Naeini
About: Danger Ahead: Threat Signals Converge to Drive Pain, Hunger
How an organism maintains its internal stability despite variations in...
News
May 15 2018
By: Mark Hoon
About: Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.
Four years ago, the labs of Patrik Ernfors and Sten Linnarsson from the...
Paper

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RELIEF News is PRF's companion site for patients and the broader public. It provides plain language summaries of research news, feature articles, interviews and podcasts. Recent highlights include a podcast on complementary and integrative pain medicine, a news article on how opioids can sometimes increase pain, and interviews with leading experts in the field. Take a look--and sign up for the RELIEF monthly e-Newsletter and content alerts as well.

 

New, freely available topical review from PAIN now available: Managing patients with chronic pain during the COVID-19 outbreak: considerations for the rapid introduction of remotely supported (eHealth) pain management services. A short video describing the paper, and three Powerpoints (in English, Mandarin, and Spanish) are also available. Visit here.