News

May 24 2018
Danger Ahead: Threat Signals Converge to Drive Pain, Hunger
Two new studies identify shared neural circuitry in the hindbrain’s parabrachial nucleus
1 Comment
news Research
May 17 2018
Highlights From the American Pain Society Scientific Summit: Muscle Pain
Symposium at March 4-6, 2018 event featured discussion of underlying mechanisms of muscle pain in different animal models
news Conferences | Research
May 14 2018
Three Is Not a Crowd: A Trio of Molecular Sensors Protects Organisms Against Acute Heat
TRPV1, TRPM3, and TRPA1 ion channels act collectively as a fault-tolerant mechanism in mice
news Research
May 03 2018
Mu and Delta Opioid Receptors: Where Are They, and Do They Interact?
New study finds MOR and DOR co-expression limited to small populations of dorsal and ventral horn neurons, and that these opioid receptor subtypes function independently to regulate pain
news Research

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Community & Resource Updates

NIH Annual Pain Consortium Symposium 2018
31 May 2018 to 1 Jun 2018
Bethesda, Maryland, US

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Postdoctoral Fellow
Johns Hopkins University, School of Medicine, Neurosurgery Pain Research Institute
Baltimore, Maryland, US

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Forums

Apr 24 2018
Sex and Gender Differences in Pain: A Chat With Edmund Keogh
Lincoln Tracy

Edmund Keogh, PhD, is professor of psychology in the Department of Psychology at the University of Bath, UK, and is the deputy director of...

Interview
Jan 31 2018
Webinar: Kappa Opioid Antagonists for Migraine and Pain
PRF Team

On January 31, Frank Porreca gave a talk on kappa opioid antagonists for migraine and pain. After his talk, there was a panel discussion...

Webinar

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Recent Comments

May 25 2018
By: Howard Fields
About: Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
Drs. Yezierski and Hansson have provided a timely, readable, scholarly and...
Paper
May 24 2018
By: Reza Sharif-Naeini
About: Danger Ahead: Threat Signals Converge to Drive Pain, Hunger
How an organism maintains its internal stability despite variations in...
News
May 15 2018
By: Mark Hoon
About: Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.
Four years ago, the labs of Patrik Ernfors and Sten Linnarsson from the...
Paper
Apr 17 2018
By: Tonia Vincent
About: An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Pain in surgical joint instability models of osteoarthritis (OA) is...
Paper
Apr 06 2018
By: Gila Moalem-Taylor
About: CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries.
Although over the past decade numerous animal studies have established...
Paper
Mar 30 2018
By: Ru-Rong Ji
About: Palmitoylation of δ-catenin promotes kinesin-mediated membrane trafficking of Na1.6 in sensory neurons to promote neuropathic pain.
This is an interesting study that has demonstrated palmitoylation as a...
Paper
Mar 23 2018
By: Xinzhong Dong
About: Circuit dissection of the role of somatostatin in itch and pain.
This is a very interesting study from the labs of Andrew Todd and Mark...
Paper
Feb 12 2018
By: John Quintner
About: What's in a Name for Chronic Pain?
Dr. Clauw and his colleagues clearly favoured "centralized" as the third...
News
Feb 06 2018
By: Samuel Krimmel
About: Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex.
The medial frontal cortex (MFC) contains multiple regions under intense...
Paper
Jan 17 2018
By: Michael Costigan
About: Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.
Editor's note: This comment is co-authored by Rafael González-Cano and...
Paper
Dec 18 2017
By: Ru-Rong Ji
About: Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
The Cell paper focused on the acute effects of the novel opioid agonists,...
Paper
Nov 26 2017
By: Howard Fields
About: Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
This is a very thorough study that examines a group of structurally...
Paper
Nov 05 2017
By: Heather Rossi
About: Does the Location of Pain Matter?
Surprising that the tendency for co-morbidity of different conditions did...
Discussion
Nov 02 2017
By: Michael O'Leary
About: Q & A: A Question About Local Anesthetics
I agree, low pH associated with infection, injury or ischemia will favor...
Q & A
Oct 06 2017
By: Ted Price
About: Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.
This comment is coauthored by Ted Price, Head of Neuroscience, UT Dallas;...
Paper
Jul 27 2017
By: Jennifer DeBerry
About: Webinar: Chronic Pelvic Pain
Dr. Hesselink: Very interesting, thank you for sharing. I have often...
Webinar
Jun 20 2017
By: Jan Keppel Hesselink
About: To (Not) Sleep, Perchance to Feel More Pain?
This paper is quite important, also from a clinical point of view. It is...
News
Jun 18 2017
By: Jan Keppel Hesselink
About: Webinar: Chronic Pelvic Pain
At the NeuPSIG at Gothenburg on the 17th of June, a poster was presented...
Webinar
May 02 2017
By: Andrey Ryabinin
About: Olfactory Cues Facilitate the Social Transfer of Pain in Mice
This comment is co-authored by Andrey Ryabinin and Mary Heinricher, Oregon...
News
May 02 2017
By: Robert Sorge
About: Olfactory Cues Facilitate the Social Transfer of Pain in Mice
I admit that I read the paper by Ryabinin and colleagues with interest,...
News
Apr 13 2017
By: Andrey Ryabinin
About: Olfactory Cues Facilitate the Social Transfer of Pain in Mice
This comment is co-authored by Andrey Ryabinin and Mary Heinricher, Oregon...
News
Apr 05 2017
By: Ke Ren
About: Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells.
The authors report interesting findings that electro-acupuncture (EA) in...
Paper
Mar 22 2017
By: Steve Davidson
About: A Subset of Spinal Interneurons Triggers Intensity-Dependent Itch and Pain
Conceptual illustration of Grp neuron function as a relief valve.
News
Mar 22 2017
By: Min Zhuo
About: Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.
In recent work by Brust et al., the authors report the identification of a...
Paper
Mar 20 2017
By: Howard Fields
About: Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis.
This is an excellent and very important article related to appropriate...
Paper

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Information for the new researcher or veteran in the field, Pain 101 is our growing collection of topical articles on important issues in pain research. Check out our articles on modeling pain in lower organisms, the role of glia in chronic pain, and transcranial magnetic stimulation. Our Pain Genes Resource will have the most up-to-date information on the genetics of pain sensitivity, risk of chronic pain and response to analgesics, presented in a format that makes it easy to keep current. We're in the process of pulling together data on the first  53 genes—you can help this resource grow by submitting new genes and studies. Stay tuned for more resources to come, including our Drug Pipeline database.