News

Jul 16 2018
Endogenous Opioid Peptides and Non-Peptide Opioid Drugs Drive Different Patterns of Receptor Activation
Nanobody biosensor reveals that peptides activate opioid receptors first at the plasma membrane and then in endosomes, while drugs also propel activation in the Golgi apparatus
news Drug Development | Research
Jul 02 2018
When Touch Causes Itch: A New Role for Merkel Cells in the Skin
A recent mouse study identifies cells that regulate alloknesis through Piezo2
news Research
Jun 19 2018
A Molecular Complex Within the Brain Underlies Opioid Tolerance in Rodents
Disrupting the interaction among opioid receptors, vasopressin receptors, and beta-arrestin-2 offers a potential strategy to slow tolerance in humans, though questions remain
news Drug Development | Research
Jun 18 2018
Modeling Discogenic Low Back Pain in the Tails of Rats—And Treating It, Too
Hyaluronic acid hydrogel biomaterial prevents pain caused by intervertebral disc injury at the base of the tail
news Research

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Community & Resource Updates

25th Napa Pain Conference
16 Aug 2018 to 19 Aug 2018
Napa, California, US

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Scientist/Assistant Professor: Two Faculty Positions Available
The Hospital for Sick Children
Toronto, Ontario, Canada

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Jul 18 2018
Resilience in the Face of Pain: A Chat With Liesbet Goubert
Lincoln Tracy

Liesbet Goubert, PhD, is a professor in the Department of Experimental-Clinical and Health Psychology at Ghent University, Belgium. Her PhD...

Interview
Jun 13 2018
IASP Congress Award Winners: A Chat with Gaston Nyirigira
Neil Andrews

At the upcoming 17th World Congress on Pain, to take place in Boston, US, from September 12-16, 2018, the International Association for the...

Interview

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Recent Comments

Jun 18 2018
By: PRF Executive Editor
About: NIH Announces HEAL Initiative to Combat Opioid Crisis
Since publication of this news story, JAMA has published a Viewpoint by...
News
May 25 2018
By: Howard Fields
About: Inflammatory and Neuropathic Pain From Bench to Bedside: What Went Wrong?
Drs. Yezierski and Hansson have provided a timely, readable, scholarly and...
Paper
May 24 2018
By: Reza Sharif-Naeini
About: Danger Ahead: Threat Signals Converge to Drive Pain, Hunger
How an organism maintains its internal stability despite variations in...
News
May 15 2018
By: Mark Hoon
About: Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.
Four years ago, the labs of Patrik Ernfors and Sten Linnarsson from the...
Paper
Apr 17 2018
By: Tonia Vincent
About: An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Pain in surgical joint instability models of osteoarthritis (OA) is...
Paper
Apr 06 2018
By: Gila Moalem-Taylor
About: CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries.
Although over the past decade numerous animal studies have established...
Paper
Mar 30 2018
By: Ru-Rong Ji
About: Palmitoylation of δ-catenin promotes kinesin-mediated membrane trafficking of Na1.6 in sensory neurons to promote neuropathic pain.
This is an interesting study that has demonstrated palmitoylation as a...
Paper
Mar 23 2018
By: Xinzhong Dong
About: Circuit dissection of the role of somatostatin in itch and pain.
This is a very interesting study from the labs of Andrew Todd and Mark...
Paper
Feb 12 2018
By: John Quintner
About: What's in a Name for Chronic Pain?
Dr. Clauw and his colleagues clearly favoured "centralized" as the third...
News
Feb 06 2018
By: Samuel Krimmel
About: Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex.
The medial frontal cortex (MFC) contains multiple regions under intense...
Paper
Jan 17 2018
By: Michael Costigan
About: Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.
Editor's note: This comment is co-authored by Rafael González-Cano and...
Paper
Dec 18 2017
By: Ru-Rong Ji
About: Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
The Cell paper focused on the acute effects of the novel opioid agonists,...
Paper
Nov 26 2017
By: Howard Fields
About: Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
This is a very thorough study that examines a group of structurally...
Paper
Nov 05 2017
By: Heather Rossi
About: Does the Location of Pain Matter?
Surprising that the tendency for co-morbidity of different conditions did...
Discussion
Nov 02 2017
By: Michael O'Leary
About: Q & A: A Question About Local Anesthetics
I agree, low pH associated with infection, injury or ischemia will favor...
Q & A
Oct 06 2017
By: Ted Price
About: Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.
This comment is coauthored by Ted Price, Head of Neuroscience, UT Dallas;...
Paper
Jul 27 2017
By: Jennifer DeBerry
About: Webinar: Chronic Pelvic Pain
Dr. Hesselink: Very interesting, thank you for sharing. I have often...
Webinar
Jun 20 2017
By: Jan Keppel Hesselink
About: To (Not) Sleep, Perchance to Feel More Pain?
This paper is quite important, also from a clinical point of view. It is...
News
Jun 18 2017
By: Jan Keppel Hesselink
About: Webinar: Chronic Pelvic Pain
At the NeuPSIG at Gothenburg on the 17th of June, a poster was presented...
Webinar
May 02 2017
By: Andrey Ryabinin
About: Olfactory Cues Facilitate the Social Transfer of Pain in Mice
This comment is co-authored by Andrey Ryabinin and Mary Heinricher, Oregon...
News
May 02 2017
By: Robert Sorge
About: Olfactory Cues Facilitate the Social Transfer of Pain in Mice
I admit that I read the paper by Ryabinin and colleagues with interest,...
News
Apr 13 2017
By: Andrey Ryabinin
About: Olfactory Cues Facilitate the Social Transfer of Pain in Mice
This comment is co-authored by Andrey Ryabinin and Mary Heinricher, Oregon...
News
Apr 05 2017
By: Ke Ren
About: Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells.
The authors report interesting findings that electro-acupuncture (EA) in...
Paper
Mar 22 2017
By: Steve Davidson
About: A Subset of Spinal Interneurons Triggers Intensity-Dependent Itch and Pain
Conceptual illustration of Grp neuron function as a relief valve.
News
Mar 22 2017
By: Min Zhuo
About: Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.
In recent work by Brust et al., the authors report the identification of a...
Paper

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Information for the new researcher or veteran in the field, Pain 101 is our growing collection of topical articles on important issues in pain research. Check out our articles on modeling pain in lower organisms, the role of glia in chronic pain, and transcranial magnetic stimulation. Our Pain Genes Resource will have the most up-to-date information on the genetics of pain sensitivity, risk of chronic pain and response to analgesics, presented in a format that makes it easy to keep current. We're in the process of pulling together data on the first  53 genes—you can help this resource grow by submitting new genes and studies. Stay tuned for more resources to come, including our Drug Pipeline database.