News

Apr 17 2018
The Fight Against Bacterial Lung Infections: A New Role for Nociceptors?
TRPV1+ neurons regulate host defense against infection and pneumonia by suppressing neutrophils and gamma delta T cell responses
news Research
Apr 09 2018
Chronic Overlapping Pain Conditions and Stress: A Meeting Report From the CACPR 3rd Annual Symposium
Recent event discusses complex pain-stress relationship observed in a number of disorders
news Conferences | Research
Apr 03 2018
A Pathogenic Autoantibody Causes Pain by Releasing the Brakes on Sensory Neurons
Patient-derived CASPR2 autoantibodies decrease potassium channel expression in mouse sensory neurons
news Research
Mar 22 2018
Tamper-Resistant Opioid Yields Mixed Results
New formulation of oxycodone curbs tampering among high-risk individuals but doesn’t change overall opioid use or related harm at a population level, according to a new Australian study
news Drug Development | Research

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Community & Resource Updates

SMi's 18th Annual Pain Therapeutics Conference
21 May 2018 to 22 May 2018
Holiday Inn Kensington Forum, London, UK
Abstract Submission Deadline:
14 May 2018
Registration Deadline:
21 May 2018

See all Meetings & Events

Postdoctoral Positions in Pain and Migraine Research
Washington University School of Medicine
Saint Louis, Missouri, US

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Jan 31 2018
Webinar: Kappa Opioid Antagonists for Migraine and Pain
PRF Team

On January 31, Frank Porreca gave a talk on kappa opioid antagonists for migraine and pain. After his talk, there was a panel discussion...

Webinar
Dec 05 2017
Veterinary Patients in Pain Research: A Conversation With Eric Troncy
Dara Bree

Editor’s note: Eric Troncy, DV, MSc, PhD, DUn is a professor at the University of Montreal in Quebec...

Interview

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Recent Comments

Apr 17 2018
By: Tonia Vincent
About: An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Pain in surgical joint instability models of osteoarthritis (OA) is...
Paper
Apr 06 2018
By: Gila Moalem-Taylor
About: CD4+ αβ T cell infiltration into the leptomeninges of lumbar dorsal roots contributes to the transition from acute to chronic mechanical allodynia after adult rat tibial nerve injuries.
Although over the past decade numerous animal studies have established...
Paper
Mar 30 2018
By: Ru-Rong Ji
About: Palmitoylation of δ-catenin promotes kinesin-mediated membrane trafficking of Na1.6 in sensory neurons to promote neuropathic pain.
This is an interesting study that has demonstrated palmitoylation as a...
Paper
Mar 23 2018
By: Xinzhong Dong
About: Circuit dissection of the role of somatostatin in itch and pain.
This is a very interesting study from the labs of Andrew Todd and Mark...
Paper
Feb 12 2018
By: John Quintner
About: What's in a Name for Chronic Pain?
Dr. Clauw and his colleagues clearly favoured "centralized" as the third...
News
Feb 06 2018
By: Samuel Krimmel
About: Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex.
The medial frontal cortex (MFC) contains multiple regions under intense...
Paper
Jan 17 2018
By: Michael Costigan
About: Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma.
Editor's note: This comment is co-authored by Rafael González-Cano and...
Paper
Dec 18 2017
By: Ru-Rong Ji
About: Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
The Cell paper focused on the acute effects of the novel opioid agonists,...
Paper
Nov 26 2017
By: Howard Fields
About: Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
This is a very thorough study that examines a group of structurally...
Paper
Nov 05 2017
By: Heather Rossi
About: Does the Location of Pain Matter?
Surprising that the tendency for co-morbidity of different conditions did...
Discussion
Nov 02 2017
By: Michael O'Leary
About: Q & A: A Question About Local Anesthetics
I agree, low pH associated with infection, injury or ischemia will favor...
Q & A
Oct 06 2017
By: Ted Price
About: Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.
This comment is coauthored by Ted Price, Head of Neuroscience, UT Dallas;...
Paper
Jul 27 2017
By: Jennifer DeBerry
About: Webinar: Chronic Pelvic Pain
Dr. Hesselink: Very interesting, thank you for sharing. I have often...
Webinar
Jun 20 2017
By: Jan Keppel Hesselink
About: To (Not) Sleep, Perchance to Feel More Pain?
This paper is quite important, also from a clinical point of view. It is...
News
Jun 18 2017
By: Jan Keppel Hesselink
About: Webinar: Chronic Pelvic Pain
At the NeuPSIG at Gothenburg on the 17th of June, a poster was presented...
Webinar
May 02 2017
By: Andrey Ryabinin
About: Olfactory Cues Facilitate the Social Transfer of Pain in Mice
This comment is co-authored by Andrey Ryabinin and Mary Heinricher, Oregon...
News
May 02 2017
By: Robert Sorge
About: Olfactory Cues Facilitate the Social Transfer of Pain in Mice
I admit that I read the paper by Ryabinin and colleagues with interest,...
News
Apr 13 2017
By: Andrey Ryabinin
About: Olfactory Cues Facilitate the Social Transfer of Pain in Mice
This comment is co-authored by Andrey Ryabinin and Mary Heinricher, Oregon...
News
Apr 05 2017
By: Ke Ren
About: Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells.
The authors report interesting findings that electro-acupuncture (EA) in...
Paper
Mar 22 2017
By: Steve Davidson
About: A Subset of Spinal Interneurons Triggers Intensity-Dependent Itch and Pain
Conceptual illustration of Grp neuron function as a relief valve.
News
Mar 22 2017
By: Min Zhuo
About: Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.
In recent work by Brust et al., the authors report the identification of a...
Paper
Mar 20 2017
By: Howard Fields
About: Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis.
This is an excellent and very important article related to appropriate...
Paper
Jan 30 2017
By: H. Richard Koerber
About: Most DRG Sensory Neurons Are Modality-Specific, Not Polymodal
I agree with Michael Gold’s comments pointing out that to accept the...
News
Jan 24 2017
By: Geoffrey Bove
About: Most DRG Sensory Neurons Are Modality-Specific, Not Polymodal
Thank you for the publication and thanks to others for this lively...
News
Jan 22 2017
By: Michael Gold
About: Most DRG Sensory Neurons Are Modality-Specific, Not Polymodal
There are, of course, responses to all of the points Wood and Emery raised...
News

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Research Resources

Information for the new researcher or veteran in the field, Pain 101 is our growing collection of topical articles on important issues in pain research. Check out our articles on modeling pain in lower organisms, the role of glia in chronic pain, and transcranial magnetic stimulation. Our Pain Genes Resource will have the most up-to-date information on the genetics of pain sensitivity, risk of chronic pain and response to analgesics, presented in a format that makes it easy to keep current. We're in the process of pulling together data on the first  53 genes—you can help this resource grow by submitting new genes and studies. Stay tuned for more resources to come, including our Drug Pipeline database.