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Papers of the Week


Papers: 28 Sep 2019 - 4 Oct 2019


Animal Studies


2019 Nov


Anesthesiology


131


5

Editor's Pick

Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer.

Authors

Hu X-M, Yang W, Du L-X, Cui W-Q, Mi W-L, Mao-Ying Q-L, Chu Y-X, Wang Y-Q
Anesthesiology. 2019 Nov; 131(5):1125-1147.
PMID: 31567367.

Abstract

Pain resulting from cancer metastatic to bone is a major clinical problemVascular endothelial growth factor receptors are involved in tumor angiogenesis and are felt to be analgesic targets WHAT THIS ARTICLE TELLS US THAT IS NEW: In a female rat model of metastatic breast cancer, expression of vascular endothelial growth factor A and its receptor vascular endothelial growth factor receptor 2 were up-regulated in spinal tissueBlocking vascular endothelial growth factor signaling improved several measures of nociception and function in this model suggesting a role for vascular endothelial growth factor antagonists in reducing cancer-related pain BACKGROUND:: Cancer pain is a pervasive clinical symptom impairing life quality. Vascular endothelial growth factor A has been well studied in tumor angiogenesis and is recognized as a therapeutic target for anti-cancer treatment. This study tested the hypothesis that vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 contribute to bone cancer pain regulation associated with spinal central sensitization.