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Papers: 17 Aug 2019 - 23 Aug 2019
Animal Studies, Human Studies, Pharmacology/Drug Development
2019 Dec
Br J Pharmacol
176
24
Triptans are 5-HT receptor agonists (that also display 5-HT receptor affinity) with antimigraine action, contraindicated in patients with coronary artery disease due to their vasoconstrictor properties. Conversely, lasmiditan was developed as an antimigraine 5-HT receptor agonist. To assess the selectivity and cardiovascular effects of lasmiditan, we investigated the binding, functional activity and in vitro/in vivo vascular effects of lasmiditan, and compared it to sumatriptan.