News

Nociceptive afferents, which carry pain signals to the spinal cord, and the projection neurons that relay those signals to the brain, are understandably the focus of most research on…

Where does it hurt? How bad does it hurt? Why does it hurt? The many inconsistent and inadequate ways of sorting chronic pain by anatomy, severity, and associated medical…

For many chronic or neuropathic pain conditions, the causes are obscure and treatments equally elusive. That is not the case for shingles and its sequelae, postherpetic neuralgia (PHN). The…

The following was adapted from a news story that originally appeared on the Alzheimer Research Forum.

The atypical protein kinase C (aPKC), PKMζ (PKMzeta), has garnered a great deal of attention in neurobiology due to its potential role as a molecular determinant of long-term synaptic…

Editors’ Note: The PRF put a few questions to the three young investigators honored with awards at the International Association for the Study of Pain’s 14th World Congress on…

People vary markedly in their ability to tolerate and control pain. This underlying variability, which is reflected in differing behavioral responses to pain, to placebo, and to analgesic drugs,…

To study pain in animals, researchers can injure a nerve or present a noxious stimulus to a rat or a mouse, and see how the creature responds. But animal…

The 6th Annual Pain Therapeutics Summit, held 3-4 October in San Jose, California, US, and organized by Arrowhead Publishers and Conferences, brought together approximately 100 researchers from industry and…

The African black mamba’s bite has been called “the kiss of death”—and for good reason. It has been estimated that just 10 to 15 mg of venom from the…

From August 27-31, pain researchers and clinicians from around the world gathered in Milan, Italy, for the 14th World Congress on Pain. With more than 7,700 attendees, the Congress…

Targeted drug delivery offers the hope of teaching old dogs new tricks, repurposing existing treatments by deploying them to previously inaccessible sites of pain. In a paper published July…

People with pain differ in how they respond to opioids, both in the degree of analgesic relief they feel and in whether they experience aversive or reinforcing drug effects.…

Chronic pain and depression often occur together, but the mechanisms behind their comorbid relationship have been elusive, leaving physicians to prescribe treatments that address symptoms, rather than root causes.