News Archive

An Autoimmune Basis for Chronic Pain?

Antibodies to potassium channel complex implicated in pain

by Megan Talkington on 4 Sep 2012

In people, autoantibodies to neuronal voltage-gated potassium channel (VGKC) complexes are associated with diverse neurologic disturbances, including seizures, encephalitis, and muscle cramps and twitching. The symptoms, many of which…

Research

A New Twist on Treating Chronic Bladder Pain

Pretzel-shaped lidocaine-releasing device shows promising results in women with interstitial cystitis/bladder pain syndrome

by Sonya Jakawich on 16 Aug 2012

Targeted drug delivery offers the hope of teaching old dogs new tricks, repurposing existing treatments by deploying them to previously inaccessible sites of pain. In a paper published July…

Drug Development

Research

Database Offers Snapshot of Pain Clinical Trials

RReACTing to elusive outcomes data

by Megan Talkington on 8 Aug 2012

Comment

Researchers seeking clinical trial data on particular drugs or conditions can check online registries such as the US National Institutes of Health (NIH)’s ClinicalTrials.gov, but the information they find…

Drug Development

Research

Twins Reveal Where Genes Matter (Or Don’t) for Opioid Responses

Pharmacogenomic study quantifies genetic contribution to variability in analgesia and side effects

by Karl Gruber and Neil Andrews on 30 Jul 2012

Comment

People with pain differ in how they respond to opioids, both in the degree of analgesic relief they feel and in whether they experience aversive or reinforcing drug effects.…

Research

Israel Honors Marshall Devor for Research Achievements

2012 EMET Prize recognizes significant contribution to society

by Pat McCaffrey on 27 Jul 2012

Comment

Pain research pioneer and PRF science advisor Marshall Devor of the Hebrew University of Jerusalem, Israel, has been awarded the 2012 EMET Prize for Art, Science and Culture, an…

People

Research

Tryptophan-Metabolizing Enzyme Connects Pain and Depression

Cytokine regulation of IDO1 in the hippocampus may underlie a comorbid association

by Megan Talkington on 26 Jul 2012

Chronic pain and depression often occur together, but the mechanisms behind their comorbid relationship have been elusive, leaving physicians to prescribe treatments that address symptoms, rather than root causes.

Research

Thrombospondin-4 and Neuromedin B Contribute to Pain Signaling

Gene expression data point to novel molecular players

by Megan Talkington on 19 Jul 2012

Microarray data can tip off researchers to new molecular mechanisms, and two recent studies from the Journal of Neuroscience draw on that information to uncover proteins driving nociception and…

Research

News Brief: Bushnell to Lead Pain Program at NIH’s Complementary and Alternative Medicine Center

by Neil Andrews on 12 Jul 2012

Comment

The National Center for Complementary and Alternative Medicine (NCCAM) of the US National Institutes of Health (NIH) in Bethesda, Maryland, announced today that M. Catherine Bushnell, PhD, has been…

People

Research

Moving Pain Treatments Forward: An FDA Public Scientific Workshop

by Neil Andrews on 9 Jul 2012

Comment

This is Part 2 of a two-part report on selected talks from the NIH Pain Consortium’s 7th Annual Symposium on Advances in Pain Research, and from an FDA CDER…

Conferences

Research

Moving Pain Treatments Forward: NIH Pain Consortium Symposium

by Neil Andrews on 9 Jul 2012

Comment

This is the first of a two-part report on selected talks from the NIH Pain Consortium’s 7th Annual Symposium on Advances in Pain Research, and from an FDA CDER…

Conferences

Research

A Winning Recipe for Nociceptors From Human Stem Cells

A mix of small molecules produces cells that look and act like pain-sensing neurons

by Megan Talkington on 2 Jul 2012

Wishing for made-to-order human neurons to model pain? The wait could soon be over. In a paper published online July 1 in Nature Biotechnology, a team led by Lorenz…

Research

What’s Sex Got to Do With It? Differences in Synapses

by Madolyn Bowman Rogers on 18 Jun 2012

Comment

Adapted from a news story that originally appeared on the Alzheimer Research Forum.

Research

News Brief: Throbbing Pain? Don’t Blame Blood Flow

Tracking down the origins of a subjective pain quality

by Megan Talkington on 8 Jun 2012

In many acute and chronic pain conditions, pain has a throbbing quality that has long been attributed to the activation of sensory neurons by blood flow pulsations. Now, Andrew…

Research

Transplanted GABAergic Cells Ease Pain

Interneuron precursors restore inhibitory control in mouse model of neuropathic pain

by Karl Gruber on 6 Jun 2012

Comment

Gamma aminobutyric acid (GABA) is a key inhibitory neurotransmitter produced by interneurons of the human central nervous system. After nerve injury, a major path leading to neuropathic pain and the…

Research

Clues to the Riddle of Pain in Diabetic Neuropathy

Studies connect condition to metabolic disruption and spinal cord changes

by Megan Talkington on 30 May 2012

Comment

Though as many as one in five people with diabetes experience painful diabetic neuropathy, the causes of this severe complication have remained unclear, leaving patients with few treatment options.…

Research

Chronic Pain Hits Hippocampus

Changes seen in animal models and pain patients

by Raji Edayathumangalam on 26 May 2012

Chronic pain patients exhibit learning and emotional changes not often reversed by painkillers, including deficits in working memory, emotional decision-making, and classical conditioning tasks, as well as elevated anxiety…

Research

Peripheral Injection of PAP Provides Local Pain Relief in Mice

Taking a tip from acupuncture

by Megan Talkington on 21 May 2012

Two years ago, researchers studying acupuncture in mice reported that needle stimulation relieves pain by eliciting adenosine release and adenosine receptor activation (Goldman et al., 2010).

Research

News Brief: δ-Opioid and Nociceptin Receptor Structures Revealed

Investigators now have complete set of four opioid receptor structures

by Megan Talkington on 17 May 2012

In March, researchers visualized opioid receptors for the first time, when two independent groups reported X-ray crystal structures of two family members, the mu (μ) and kappa (κ) receptors…

Research

Sodium Channel Nav1.7 in Sympathetic Neurons Contributes to Pain Phenotypes in Mice

Mouse model suggests sodium channel role in neuropathic pain

by Megan Talkington and Pat McCaffrey on 16 May 2012

In people, loss-of-function mutations in the voltage-gated sodium channel Nav1.7 result in total insensitivity to pain. Replicating that absolute loss of pain perception in animals has proven a challenge—globally…

Research

Morphine Mimics Endotoxin Action at Innate Immune Receptor TLR4

Drug triggers neuroinflammation via MD-2 accessory protein

by Megan Talkington and Pat McCaffrey on 27 Apr 2012

Comment

Morphine and other opioids can provoke neuroinflammation by activating the innate immune system’s Toll-like receptor 4 (TLR4), but just how the compounds turn on TLR4 signaling has been unclear.…

Research

Opioids and Cancer Progression: How Strong a Link?

Research identifies plausible biological mechanisms, but clinical evidence remains weak

by Megan Talkington on 9 Apr 2012

Comment

Over the last decade, clinical studies have hinted that opioids, used after cancer surgery, may promote the growth or recurrence of tumors, but the data have been mixed. The…

Research

P2X7 Receptor Gene Variants Modulate Chronic Pain

"Super-pore" formation tied to pain sensitivity

by Megan Talkington on 1 Apr 2012

Many gene variants are linked to chronic pain and analgesic response, but more often than not, their function is unclear. A study published online March 25 in Nature Medicine…

Research

Unveiling the Opioid Receptors

First-ever structures of μ- and κ-opioid receptors could drive development of more effective, safer therapeutics

by Megan Talkington on 25 Mar 2012

People have used extracts of poppies to ease pain since the time of the Byzantine Empire. The active component, morphine, was isolated in 1804. And the receptors that mediate…

Research

Shining New Light on Pain

New photosensitive molecules increase speed and precision for mapping nociceptive pathways

by Raji Edayathumangalam on 19 Mar 2012

Comment

Pain researchers interested in mapping nociceptive pathways and understanding opioid signaling have always grappled with a dearth of experimental tools. Now two groups report novel photoactivatable molecules to remedy…

Research

Progress in Pain Genetics: Translational Value

From genes to the clinic

by Pat McCaffrey on 19 Mar 2012

Comment

This is the final installment of a four-part report on selected talks from the 10th IASP Research Symposium, The Genetics of Pain: Science, Medicine and Drug Development, held 7-9 February…

Conferences

Research

Progress in Pain Genetics: Problematic Phenotyping

A matter of definitions, or association with what?

by Pat McCaffrey on 16 Mar 2012

Comment

This is Part 3 of a four-part report on selected talks from the 10th IASP Research Symposium, The Genetics of Pain: Science, Medicine and Drug Development, held 7-9 February…

Conferences

Research

Progress in Pain Genetics: Human Studies Move Ahead

A few pieces of a larger puzzle

by Pat McCaffrey on 15 Mar 2012

Comment

This is Part 2 of a four-part report on selected talks from the 10th IASP Research Symposium, The Genetics of Pain: Science, Medicine and Drug Development, held 7-9 February…

Conferences

Research

Progress in Pain Genetics: A Meeting of Their Own

Miami symposium is first for field

by Pat McCaffrey on 14 Mar 2012

Comment

This is the first of a four-part report on selected talks from the 10th IASP Research Symposium, The Genetics of Pain: Science, Medicine and Drug Development.

Conferences

Research

FDA Advisory Panel Gives the Green Light to Restart NGF Antibody Trials

Investigators pleased that promising agents for pain relief have new life

by Megan Talkington on 13 Mar 2012

Comment

An advisory panel of the U.S. Food and Drug Administration (FDA) has voted unanimously that antibodies against nerve growth factor (NGF) should re-enter clinical trials for pain. The 21-person…

Drug Development

Research

News Brief: Decision Day Approaches for NGF Antibodies

FDA advisory committee to decide fate of halted development program

by Megan Talkington on 9 Mar 2012

Comment

Antibodies inhibiting nerve growth factor (NGF) are profoundly effective pain relievers in clinical trials, and, if approved, would become the first new class of analgesics for osteoarthritis, and possibly…

Drug Development

Research

From the Masseuse to the Nociceptor

New muscle biopsy study dissects the underlying cellular and molecular mechanisms of therapeutic massage

by Karl Gruber on 2 Mar 2012

Comment

Randomized trials have shown that massage can ease low back and neck pain, but the cellular and molecular basis for this benefit has remained unclear—until now. In clinical research…

Research

Cancer Drug Reverses Morphine Tolerance

Action of kinase inhibitor reveals role for platelet-derived growth factor in loss of pain-killing effects of opioids

by Sonya Jakawich on 2 Mar 2012

Comment

The development of tolerance to the analgesic effects of opioids limits effective treatment of chronic pain, and many labs are working to unravel the molecular mechanisms underlying morphine tolerance.…

Research

Novel Ion Channel Senses Painful Touch

Mammalian force-activated channel and potential pain detector identified

by Megan Talkington on 23 Feb 2012

Comment

A new family of ion channels may answer a pressing question in pain biology: How do we detect painful touch? In two papers published February 19 online in Nature,…

Research

News Brief: Structures Solved for K2P Potassium “Leak” Channels

A first look at two-pore-domain channels

by Megan Talkington on 13 Feb 2012

Comment

Neurons maintain their negative resting membrane potential with the help of two-pore-domain potassium (K2P) channels, which let potassium ions leak out across the plasma membrane and thus control cell…

Research

A Massive Dataset Settles It: Concerning Pain, Men and Women Are Different

Mining medical records provides a clear answer

by Karl Gruber on 8 Feb 2012

Comment

A study of electronic medical records that analyzed over 11,000 patient-reported pain scores has found that women consistently report higher pain scores than men for a number of diseases.…

Research

PRF Expands Science Advisory Panel

International steering group offers diversity of expertise

by Pat McCaffrey on 1 Feb 2012

Comment

The Pain Research Forum is pleased to announce the addition of six leading pain researchers to our panel of science advisors.

People

In the Spotlight: A Crisis in Pain Care

Documentary film LIFE Before Death premieres worldwide

by Megan Talkington on 31 Jan 2012

Alongside the scientific search for pain mechanisms and the clinical quest for better treatments lies a problem of policy: Does care reach the patients who need it? A team…

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Metabolomics Uncovers a New Driver for Neuropathic Pain

A product of sphingomyelin breakdown fuels allodynia in rats

by Megan Talkington on 30 Jan 2012

Comment

In the hunt for the molecular underpinnings of pain, there are plenty of suspects to investigate. There are DNA sequences, the transcripts produced from them, and the proteins they…

Research

Erasing the Spinal Memory of Pain?

High-dose opioid reverses synaptic potentiation in the spinal cord in rats

by Megan Talkington on 16 Jan 2012

A single, high dose of opioids might be able to cut off chronic pain at the roots. That is the hope offered by a study published in the January…

Research

News Brief: Lights, Camera, Assay

Researchers become screen stars to instruct via video

by Megan Talkington on 13 Jan 2012

Comment

Last month, a team of researchers investigating infant pain published a description of their method for monitoring babies’ brain activity by electroencephalography (EEG). The PRF covered their work in…

Research

Modeling How Environment, Exercise, and Sleep Affect Pain

Coverage of poster presentations at Neuroscience 2011

by Pat McCaffrey on 10 Jan 2012

Comment

Adverse life events, stress, and lack of sleep can increase the intensity of felt pain and diminish the ability of people to function with chronic pain, while interventions that…

Conferences

Research

Sex and the Society for Neuroscience

Taking account of sex differences at Neuroscience 2011

by Pat McCaffrey on 10 Jan 2012

Comment

At the annual meeting of the Society for Neuroscience, held November 12-16 in Washington, DC, sex differences, long a concern of pain researchers, were a hot topic, featured in…

Conferences

Research

TRPA1 Channel Variants Reveal Clues to Thermal Sensitivity

Some like it hot

by Megan Talkington on 5 Jan 2012

Comment

What temperatures have you touched today? Did you brush snow off your boots, or grip a cup of hot coffee? Next time you notice chill or warmth, give a…

Research

Naked Mole Rats Reveal Mechanism of Pain Resistance

Protons block sodium channel and inhibit firing of acid-sensing neurons

by Megan Talkington on 18 Dec 2011

The African naked mole rat does not look like the toughest critter. It comes clothed in pale, wrinkled, hairless skin and is nearly blind. Yet it thrives in extreme…

Research

Navigating TRP Channels: New Ways to Open the Locks

An acetaminophen metabolite targets TRPA1, a lipid latches onto TRPV1

by Megan Talkington on 14 Dec 2011

Transient receptor potential (TRP) channels are familiar players in pain, and we know a lot about how temperature and irritants like capsaicin and mustard oil activate the channels and…

Research

FLAT-tening Pain

Blocking transporter boosts endocannabinoid levels in mice

by Megan Talkington on 1 Dec 2011

Endocannabinoids are some of the body’s chief analgesic armaments. The lipid mediators—among them, anandamide (also called N-arachidonoylethanolamide, AEA)—are produced by neurons and released into synapses, where they act on…

Research

OPPERA Study Publishes Its Libretto

Prospective study of orofacial pain releases first results

by Megan Talkington on 21 Nov 2011

Comment

The long-awaited initial findings from the largest and most comprehensive prospective study to date of chronic pain are shedding light on the common condition of jaw pain.

Research

Lone Star Snakes Reveal Unexpected Role for Acid-Sensing Channels in Pain

Toxin in Texas coral snake venom activates ASIC1

by Megan Talkington on 18 Nov 2011

Comment

Plants like chili peppers and wasabi elicit pungent, almost painful flavors with capsaicin and mustard oil, which have given researchers powerful tools for probing pain-sensing pathways. For other painful…

Research

The Life and Times of the Human Brain Transcriptome

by Michele Solis (Schizophrenia Research Forum) on 31 Oct 2011

Comment

Adapted from a news story that originally appeared on the Schizophrenia Research Forum.

Research

Sex and Drugs and Stress and Genetic Variation: Very Complicated Indeed

Vasopressin signaling controls pain—sometimes

by Megan Talkington on 28 Oct 2011

A complex interplay of sex, genotype, and emotional state can determine how people process pain and respond to an analgesic. That is the conclusion of a new investigation into…

Research

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The IASP Pain Research Forum is a publication of the International Association for the Study of Pain