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May 15 2013
News Brief: Sleep-Disrupting Gene Mutation Implicated in Migraine
Deficit in casein kinase I delta enzyme tied to migraine in families with hereditary sleep disorder
2 Comments
news Research
May 14 2013
Spinal Interneurons: Much More Than Middlemen
A conditional knockout of excitatory dorsal horn interneurons reveals their essential role in signaling pain and itch
news Research
May 13 2013
One Gene, Many Receptors: μ-Οpioid Receptor Variants Offer Targets for Improving Drugs
News from Experimental Biology 2013, Boston
news Conferences | Research
May 07 2013
A Brain Signature for Physical Pain?
Complex pattern of brain activity marks response to painful heat
2 Comments
news Research

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Community & Resource Updates

8th Annual NIH Pain Consortium Symposium: Advances in Pain Research
29 May 2013 to 30 May 2013
Bethesda, Maryland, US
Alert:
The symposium will be videocast live.

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APS Future Leaders in Pain Research Grants Program
American Pain Society
Call for Grant Applications opening date:
3 Jun 2013

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Faculty Positions in Neuroscience
Texas A&M University
College Station, Texas, US

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May 20 2013
Webinar and Live Discussion: Measuring the Affective Dimensions of Pain in Animal Models
PRF Editors

Editors' note: Preclinical Assessment of Affective Dimensions of Pain to Enhance Translation, a May 15th Pain Research Forum webinar...

2 Members Recommend
webinar
Mar 12 2013
US National Institutes of Health Releases First Federal Plan to Advance Research on Overlapping Pain Conditions
Christin Veasley

Editors’ note: Christin Veasley, the Executive Director of the National Vulvodynia Association and Co-founder of the...

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Recent Comments

May 20 2013
By: Daniel I. Chasman
About: News Brief: Sleep-Disrupting Gene Mutation Implicated in Migraine
Heterogeneity of clinical characteristics has challenged an understanding...
News
May 15 2013
By: Markus Schuerks
About: News Brief: Sleep-Disrupting Gene Mutation Implicated in Migraine
Brennan et al. describe two mutations in the casein kinase I δ (CKIδ) gene...
News
May 08 2013
By: Marshall Devor
About: A Brain Signature for Physical Pain?
This article makes the radical claim that an objective, neurologic...
News
May 07 2013
By: Massieh Moayedi
About: A Brain Signature for Physical Pain?
This comment was coauthored by David Seminowicz, University of Maryland,...
News
May 06 2013
By: William Schmidt
About: Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial.
To my knowledge, this is the first Phase 3 study to show a statistically...
Paper
Apr 25 2013
By: Ru-Rong Ji
About: WNT signaling underlies the pathogenesis of neuropathic pain in rodents.
This is an interesting paper, which demonstrates a role for the Wnt...
Paper
Apr 20 2013
By: Maral Tajerian
About: Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex.
Curious about which particular genes are affected? Follow up paper now...
Paper
Apr 16 2013
By: Joseph Martin
About: A New Cause for Unexplained Pain in Children
This is a seminal advance in our appreciation of an under-recognized...
News
Apr 15 2013
By: Magdalene Moran
About: Watching Pain Become Chronic
This paper highlights the importance of understanding disease progression...
News
Apr 15 2013
By: Pankaj Pasricha
About: Watching Pain Become Chronic
This is an important study from a very distinguished group studying...
News
Mar 21 2013
By: Emmanuel Deval
About: Serotonin Facilitates Peripheral Pain Sensitivity in a Manner That Depends on the Nonproton Ligand Sensing Domain of ASIC3 Channel.
Wang and colleagues report here the interesting observation that the...
Paper
Mar 15 2013
By: Ted Price
About: Benzoquinone Reveals a Cysteine-dependent Desensitization Mechanism of TRPA1.
This is a fascinating new finding concerning the pharmacology of TRPA1....
Paper
Mar 11 2013
By: Sid Simon
About: Unraveling the Mysteries of TRPV1 Regulation
The Regulation of TRPV1 by Phosphoinositides in Liposomes This comment is...
News
Feb 18 2013
By: James Campbell
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
Acute opioids are expected to have different side effects compared to...
Discussion
Feb 18 2013
By: James Rybacki
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
I've always included a caution in my Essential Guide to Prescription Drugs...
Discussion
Feb 18 2013
By: Xian-Guo Liu
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
It has been shown that many patients with chronic pain have cognitive...
Discussion
Feb 12 2013
By: Karen Berkley
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
This issue of the complex factors affecting car crash risk (“accident” is...
Discussion
Feb 12 2013
By: Miroslav "Misha" Backonja
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
We answered this question in the early 1990s. We did a morphine placebo-...
Discussion
Feb 12 2013
By: Mark Wallace
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
There was a study in the late 1990s (see attached slides below on earlier...
Discussion
Feb 12 2013
By: Harry Gould
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
Karen's question is a very important one, and well worth discussing....
Discussion
Feb 12 2013
By: Jordan Karp
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
The study design could be the comparison of rates of accidents from home...
Discussion
Feb 12 2013
By: Karen Berkley
About: Opioids and Road Trauma: Is It the Medicine, the Pain, or Both?
Has anyone ever looked to see how the presence of pain, particularly...
Discussion
Jan 22 2013
By: Gil Yosipovitch
About: Found: A Home for Itch in Peripheral Neurons
This comment was coauthored by Leigh Nattkemper. Han et al. have provided...
News
Jan 17 2013
By: Mark Hutchinson
About: A New Pathway for Paradoxical Pain
This is a large body of work that very nicely characterizes a beautiful...
News
Jan 17 2013
By: Jürgen Sandkühler
About: A New Pathway for Paradoxical Pain
This article describes a novel mechanism of morphine-induced hyperalgesia...
News

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Research Resources

Information for the new researcher or veteran in the field, Pain 101 is our collection of topical articles on important issues in pain research--check out our inaugural articles on modeling pain in lower organisms and the role of glia in chronic pain. Our Pain Genes Resource will have the most up-to-date information on the genetics of pain sensitivity, risk of chronic pain and response to analgesics, presented in a format that makes it easy to keep current. We're in the process of pulling together data on the first  53 genes--you can help this resource grow by submitting new genes and studies. Stay tuned for more resources to come, including our Drug Pipeline database.