Pain Research Forum

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  • Revealing the Inner Workings of Pain

    "I think we can take apart the system and understand how it functions," says Clifford Woolf in a Forums feature. "That's my mission."
    Read more...

  • Navigating Nav1.7 Biology

    Targeted knockouts reveal novel roles for the ion channel in sympathetic neurons and the central nervous system.
    Read more...

  • Portrait of a Family

    New structures for the δ-opioid and nociceptin receptors join recent μ- and κ-opioid structures to give a comprehensive look at this important receptor group.  Read more...

  • Building Better Pain Relievers

    "What are we going to do that’s different, and better, so that we can address the different types of pain that individual patients have? And how can we do this with greater safety?" asks William Schmidt.  Read more...

News

May 17 2012
News Brief: δ-Opioid and Nociceptin Receptor Structures Revealed
Investigators now have complete set of four opioid receptor structures
News
Research
May 16 2012
Sodium Channel Nav1.7 in Sympathetic Neurons Contributes to Pain Phenotypes in Mice
Mouse model suggests sodium channel role in neuropathic pain
News
Research
Apr 27 2012
Morphine Mimics Endotoxin Action at Innate Immune Receptor TLR4
Drug triggers neuroinflammation via MD-2 accessory protein
News
Research
Apr 09 2012
Opioids and Cancer Progression: How Strong a Link?
Research identifies plausible biological mechanisms, but clinical evidence remains weak
News
Research

Papers of the Week

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Community & Resource Updates

Postdoctoral Positions

 

Massachusetts General Hospital, Boston, USA
University of Texas MD Anderson Cancer Center, USA
University of Pennsylvania, Philadelphia, USA
University of Miami Miller Medical School, USA
University of North Carolina, Durham, USA

 

See all Jobs

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Scads of Satellite Symposia

 

In conjunction with the 14th World Congress on Pain of the International Association for the Study of Pain (IASP) in Milan, Italy, IASP members and Special Interest Groups will hold 20 meetings on 23-26 August 2012.

 

Find details about several symposia on the PRF Bulletin Board
Browse the full list of symposia at the IASP website

 

See all Meetings & Events

 

Forums

May 18 2012
Moving Safer, More Effective Pain Medicines to Market: A Conversation with William Schmidt
PRF Editors

This is the third in a series of Forum interviews with PRF science advisors.   William Schmidt is an independent consultant to drug...

Discussion
May 11 2012
Revealing the Inner Workings of Pain: A Conversation with Clifford Woolf
PRF Editors

This is the second in a series of Forum interviews with PRF science advisors.   Clifford Woolf, MB, BCh, PhD focuses on the basic...

Discussion

Start a new Discussion

Recent Comments

May 17 2012
By: Mary Hannaman
About: What Is the Reason for Lack of Translation in the Pain Field?
A deepening chasm separates the knowledge obtained from a physician...
Discussion
May 16 2012
By: Judith Strong
About: Sodium Channel Nav1.7 in Sympathetic Neurons Contributes to Pain Phenotypes in Mice
It is interesting that, in human patients with CIP due to loss of...
News
May 07 2012
By: Kenneth Casey
About: Pain In Parkinson's Disease: Is Neurodegeneration in Peripheral Nerves to Blame?
The hypothesis offered by Reichling and Levine is interesting and...
Discussion
May 05 2012
By: Kenneth Casey
About: Specificity Versus Patterning Theory: Continuing the Debate
  Ghosts of Pattern and Specificity This discussion by Alan Basbaum and...
Discussion
Apr 02 2012
By: Marzia Malcangio
About: P2X7 Receptor Gene Variants Modulate Chronic Pain
This elegant study provides evidence for P2X7 receptor mutations that...
News
Mar 29 2012
By: Sadaf Ashraf
About: Neuroplasticity of sensory and sympathetic nerve fibers in the painful arthritic joint.
The objective of this recent paper from Patrick W. Mantyh’s laboratory was...
Paper
Mar 26 2012
By: Michael Bruchas
About: Unveiling the Opioid Receptors
I think Laura Bohn really hits all the key points here.  Having this "snap...
News
Mar 26 2012
By: Laura Bohn
About: Unveiling the Opioid Receptors
From Pleasure to Pain What will the new crystal structures mean to...
News
Feb 26 2012
By: PRF Editors
About: Advancements in pain research.
Table of Contents for Methods in Molecular Biology, 2012, Volume 851....
Paper
Feb 23 2012
By: Michael Costigan
About: Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.
In the February 3rd 2012 edition of Cell, Arima et al. show active...
Paper
Feb 06 2012
By: Megan Talkington
About: In the Spotlight: A Crisis in Pain Care
The PRF team attended LIFE Before Death screenings last week. We found...
News
Feb 01 2012
By: Pamela Ressler
About: In the Spotlight: A Crisis in Pain Care
For colleagues in the Boston area, the Tufts Pain Research, Education and...
News
Jan 19 2012
By: Li-Yen Mae Huang
About: Erasing the Spinal Memory of Pain?
Low-frequency stimulation (LFS) of sciatic nerve fibers was found to...
News
Jan 17 2012
By: Min Zhuo
About: Erasing the Spinal Memory of Pain?
  Spinal dorsal horn synapses are the first synapses that convey...
News
Jan 16 2012
By: Ted Price
About: Erasing the Spinal Memory of Pain?
While there is a whole body of literature on 7-transmembrane receptor (...
News
Jan 16 2012
By: Lars Arendt-Nielsen
About: Erasing the Spinal Memory of Pain?
Use-dependent long-term potentiation (LTP) of synaptic strength between...
News
Jan 06 2012
By: Amelia Swift
About: Where Are Glia Going?
I am looking at cytokines in the CSF of people with osteoarthritis.  One...
News
Dec 22 2011
By: Karen Lines
About: Navigating TRP Channels: New Ways to Open the Locks
LPA appears to be essential in the estrous cycle, early pregnancy and the...
News
Dec 22 2011
By: Karen Lines
About: A New Chapter for Sodium Channels
Great article- thank you. I just looked up the relationship between sodium...
News
Dec 02 2011
By: Christopher Fowler
About: FLAT-tening Pain
  This is an important study, which fills in many gaps in our knowledge....
News
Nov 09 2011
By: zhi zhang
About: Epigenetic Downregulation of GABA Signaling Perpetuates Pain
You are absolutely right. The expression of KCC2 in the NRM under...
News
Nov 05 2011
By: Jan Keppel Hesselink
About: Where Are Glia Going?
Proof of Principle in the clinic is already there with the many trials...
News
Oct 28 2011
By: Marshall Devor
About: Sex and Drugs and Stress and Genetic Variation: Very Complicated Indeed
This paper is quite complicated, but solid, all in all interesting, and...
News
Oct 26 2011
By: Jan Keppel Hesselink
About: What Is the Reason for Lack of Translation in the Pain Field?
A question...Any idea why no-one ever used the King Charles Spaniel as a...
Discussion
Oct 24 2011
By: Huiyin Tu
About: HCN2 ion channels play a central role in inflammatory and neuropathic pain.
It is hard work to understand. I have some questions:. Why were global...
Paper

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Members & Community

PRF members have full access to other members' profiles and can contact colleagues through the site. If you are not a member yet, it's free and easy to join the only web community dedicated to pain research.

 

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Research Resources

Information for the new researcher or veteran in the field, Pain 101 is our collection of topical articles on important issues in pain research--check out our inaugural articles on modeling pain in lower organisms and the role of glia in chronic pain. Our Pain Genes Resource will have the most up-to-date information on the genetics of pain sensitivity, risk of chronic pain and response to analgesics, presented in a format that makes it easy to keep current. We're in the process of pulling together data on the first  53 genes--you can help this resource grow by submitting new genes and studies. Stay tuned for more resources to come, including our Drug Pipeline database.