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Pain Gene Resource

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Select to Compare Symbol Gene Namesort descending Chr. Chr. Location Function Phenotype/Disease Studies Cited
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5 63960048: 63962292 GPCR for serotonin thermal pain perception
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 13 47,407,513: 47,470,369 receptor for the neurotransmitter serotonin musculoskeletal pain, irritable bowel syndrome, analgesia requirements, other 13
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled X 114584078: 114910061 GPCR for serotonin analgesic response to escitalopram
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 11 113904796: 113946561 ionotropic receptor for serotonin pain castrophizing
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 22 19,966,603: 20,016,802 catenin family member that participates in formation of adherens junctions cold pressor pain 1
ATL1 atlastin GTPase 1 14 50,069,550: 50,169,534 endoplasmic reticulum GTP-binding protein Hereditary Sensory and Autonomic Neuropathy Type ID 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 7 87,503,863: 87,713,323 ATP-dependent drug efflux pump opioid response, chemotherapy-induced neuropathy 28
BDNF brain-derived neurotrophic factor 11 27,654,893: 27,722,058 neuron growth and survival factor; major regulator of synaptic transmission and plasticity in adults migraine, cortical pain processing, primary dysmenorrhea 10
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1 181,483,550: 181,806,784 R-type ('high-voltage activated' ) calcium channel subunit fentanyl sensitivity
CSNK1D casein kinase 1, delta 17 80,197,522: 80,231,593 serine/threonine specific protein kinase migraine
COMT catechol-O-methyltransferase 22 19,929,263: 19,957,496 neurotransmitter degradation various
CCT5 chaperonin-containing TCP1, subunit 5 (epsilon) 5 10,250,282: 10,266,500 molecular chaperone sensory neuropathy 1
CRHBP corticotropin releasing hormone binding protein 5 76,952,855: 76,969,474 inactivates corticotropin-releasing hormone more pain sites in chronic widespread pain
CYP2D6 cytochrome p450, family 2, subfamily D, polypeptide 6 22 42,522,502: 42,526,883 monooxygenase opioid response
DNMT1 DNA (cytosine-5-)-methyltransferase-1 19 10,244,023:10,305,755 controls gene expression through DNA methylation Hereditary sensory and autonomic neuropathy type I with dementia and hearing loss (HSAN IE) 1
EDNRA endothelin receptor type A  4 147,480,917: 147,544,954 GPCR that mediates effects of endothelin-1 in vasoconstriction migraine
ESR1 estrogen receptor 1 6 152,128,454: 152,424,406 nuclear estrogen receptor migraine, dysmenorrhea, osteoarthritis pain 13
MEFV Familal Mediterranean fever gene 16 3,292,028: 3,306,627 modulator of innate immunity fibromyalgia, dysmenorrhea 3
FAM134B family with sequence similarity 134, member B 5 16,473,148: 16,617,118 Required for long-term survival of nociceptive and autonomic ganglion neurons Hereditary Sensory and Autonomic Neuropathy Type IIB (HSAN2B) 3
FAAH fatty acid amide hydrolase 1 46,859,939: 46,879,520 inactivates the endocannabinoid anandamide experimental cold pain, functional GI disorders, Parkinson disease 3
GCH1 GTP cyclohydrolase 1 14 55,308,724: 55,369,542 rate-limiting enzyme for BH4 synthesis acute and chronic pain, experimental pain 13
HCRTR2 hypocretin (orexin) receptor 2 6 55,106,460: 5,5282,620 GPCR that regulates feeding behavior and sleep cluster headache
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 9 111,629,801: 111,696,608 scaffold protein and regulator of proinflammatory signaling Hereditary Sensory and Autonomic Neuropathy Type III (HSAN3) or Familial Dysautonomia 3
IL1RN interleukin 1 receptor antagonist 2 113,885,138: 113,891,592 inhibits the activity of IL-1 postoperative opioid use, lower back pain, vulvar vestibulitis 8
IL1R1 interleukin 1 receptor, type I 2 102,686,835: 102,796,333 cytokine receptor for interleukin 1 breast pain in women with breast cancer 1
IL1R2 interleukin 1 receptor, type II 2 102,608,305: 102,644,884  cytokine receptor for interleukin 1 postsurgical pain 1
IL1A interleukin 1, alpha 2 113,531,493: 113,542,971 cytokine produced by activated machrophages and involved in the inflammatory response low back pain 2
IL1B interleukin 1, beta 2 113,531,493: 113,542,971 cytokine produced by activated machrophages and involved in the inflammatory response low back pain, burning mouth syndrome, migraine, vulvar vestibulitis 5
IL10 Interleukin 10 4 74,606,275: 74,609,431 inhibits the synthesis of a number of cytokines postsurgical pain; irritable bowel syndrome; pelvic pain, diabetic peripheral neuropathy 10
IL13 interleukin 13 5 131,993,864: 131,996,800 anti-inflammatory cytokine breast pain in women with breast cancer 1
IL16 interleukin 16 (lymphocyte chemoattractant factor) 15 81,489,219: 81,605,101 stimulates migratory response in inflammatory cells 1
IL6 interleukin 6 7 22,766,766: 22,771,619 cytokine involved in inflammatory response pain in lung cancer, arthritis; irritable bowel syndrome; sciatica 7
IL8 interleukin 8 4 74,606,275: 74,609,431 proinflammatory cytokine cancer pain, temporomandibular disorder 4
KIF1A kinesin family member 1A 2 241,653,181: 241,759,725 motor for axonal transport of synaptic vesicles Hereditary Sensory and Autonomic Neuropathy Type IIC (HSN2C) 1
LRP1 low density lipoprotein receptor-related protein 1 12 57,522,281:57,607,141 endocytic receptor migraine
HLA-B major histocompatibility complex, class I, B 6 31,321,649: 31,324,989 involved in the presentation of foreign antigens to the immune system CRPS; postherpetic neuralgia
HLA-DQ major histocompatibility complex, class II 6 32,605,183: 32,611,428 involved in the presentation of foreign antigens to the immune system CRPS; chronic postsurgical pain
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 16 89,984,287: 89,987,385 controls melanogenesis pain and analgesia, fear of dental pain, vuvlar vestibulitis 6
MTDH metadherin 8 98,656,374: 98,742,487  transcriptional coactivator migraine
MAOA monoamine oxidase A X 43,515,409: 43,606,067 catalyzes the oxidation and degradation of monoamine neurotransmitters postoperative pain, cold pain tolerance, migraine 12
MAOB monoamine oxidase B X 43,625,858: 43,741,721 catalyze the oxidation and degradation of monoamine neurotransmitters acute postsurgical pain 1
MYT1L myelin transcription factor 1-like 2 1,792,884: 2,335,146  neural lineage-specific transcription factor fibromyalgia
ATP1A2 Na+/K+ ATPase, α2 subunit 1 160,085,520: 160,113,372 Na+/K+ ATPase catalytic subunit migraine 35
NGFB nerve growth factor (beta polypeptide) 1 115,828,537:115,880,857 neurotrophic growth factor congenital insensitivity to pain (Hereditary Sensory and Autonomic Neuropathy type V, HSAN5) 5
NRXN3 neurexin 3 14 78,636,715: 80,334,632 neuronal cell surrface protein that may be involved in cell recognition and adhesion fibromyalgia
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1 156,830,671: 156,851,642 receptor tyrosine kinase for nerve growth factor congenital insensitivity to pain with anhidrosis (CIPA); hereditary and sensory autonomic neuropathy type IV (HSAN4) 18
NOS3 nitric oxide synthase 3 (endothelial cell) 7 150,688,144: 150,711,686 involved in nitric oxide synthesis migraine
NFKB1A nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 14 35,870,717: 35,873,960 inhibits the activity of NF-Kappa-B complexes pain in lung cancer patients
OPRD1 opioid receptor, delta 1 1 29,138,654: 29,190,208 receptor for opioids acute pain senstivity; response to opioids
OPRM1 opioid receptor, mu 1 6 154,360,443: 154,414,655 receptor for opioids response to opioids
CACNA1A P/Q-type voltage gated calcium channel, α1a subunit 19 13,317,256: 13,617,274 P/Q-type calcium channel subunit migraine 24
KCNN3 potassium channel, calcium-activated, intermediate/small conductance, subfamily N, member 3 1 154,669,937: 154,842,753 voltage-independent calcium-activated channel thought to regulate neuronal excitability migraine
KCNJ3 POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 3 2 155,555,092: 155,714,863 GPCR-regulated potassium channel GIRK1 breast pain in women with breast cancer
KCNK18 potassium channel, subfamily K, member 18 10 118,957,000: 118,969,809 two-pore domain (K2P) potassium channel familial migraine with aura 1
KCNK9 POTASSIUM CHANNEL, SUBFAMILY K, MEMBER 9 8 140,613,080: 140,715,298  pH-dependent potassium channel breast pain in women with breast cancer
KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6 21 38,996,786: 39,288,696 potassium channel that regulates insulin secretion by glucose and neurotransmitters postoperative analgesic use, breast cancer pain, chronic pain, methadone use 4
KCNS1 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1; Kv9.1 20 43720951: 43729753 voltage-gated potassium channel subunit pain after nerve injury, experimental pain sensitivity 1
PRDM16 PR domain containing 16 1 2,985,564: 3,355,184 zinc finger transcription factor migraine
PRRT2 proline-rich transmembrane protein 2 16 29,823,408: 29,827,201 transmembrane protein mutated in dyskinesias convulsion and seizure disorders migraine
POMC proopiomelanocortin 2 25,383,721: 25,391,558  precurosr of beta-endorphin and met-enkephalin chronic widespread pain
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); COX2 1 186,640,945: 186,649,559 mediates the formation of prostaglandins pain in lung cancer patients; migraine
RAB7A RAB7A, member RAS oncogene family 3 128,444,974: 128,533,640 regulator of vesicular transport Hereditary motor and sensory neuropathy IIB
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 17 74,466,974: 74,497,508 inhibits EGF and TNF release opioid response
SEPT9 septin 9 17 75,277,492: 75,496,676 involved in cytokinesis and cell cycle control Hereditary neuralgic amyotrophy
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 9 94,793,427: 94,877,690 a subunit of a key enzyme in sphingolipid biosynthesis Hereditary Sensory and Autonomic Neuropathy Type IA (HSAN1A) 10
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 14 77,973,272: 78,083,110 a subunit of a key enzyme in sphingolipid biosynthesis Hereditary Sensory and Autonomic Neuropathy Type IC (HSAN1C) 2
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6  14 94,770,584: 94,789,687 serine protease inhibitor; major transport protein for glucocorticoids and progestins in blood chronic widespread pain
SCN4A sodium channel, voltage gated, type IV alpha subunit 17 62,015,913: 62,066,875  Nav1.4 voltage-gated sodium channel subunit oxaliplatin-induced peripheral neuropathy; painful cold-induced myotonia
SCN1A sodium channel, voltage-gated, type I, alpha subunit 2 166845671: 166930149 mediates the voltage-dependent sodium ion permeability of excitable membranes familial hemiplegic migraine
SCN2A sodium channel, voltage-gated, type II, alpha subunit 2 166,152,283: 166,248,818 voltage-gated sodium channel subunit oxaliplatin-induced peripheral neuropathy
SCN9A sodium channel, voltage-gated, type IX, alpha subunit 2 167,051,704: 167,232,497 voltage-gated sodium channel Nav1.7 subunit erythermalgia, PEPD, CIP, pain sensitivity 47
SCN10A sodium channel, voltage-gated, type X, alpha subunit 3 38,738,836: 38,835,500 voltage-gated sodium channel Nav1.8 subunit familial episodic pain 2 (FEPS2) 2
SCN11A sodium channel, voltage-gated, type XI, alpha subunit 3 38,887,259: 38,995,135 voltage-gated sodium channel Nav1.9 subunit congenital insensitivity to pain; familial episodic pain; small fiber neuropathy 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1 43,391,045: 43,424,846 major glucose transporter in the blood-brain barrier hemiplegic migraine
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; DAT-1 5 1,392,910: 1,445,538 dopamine transporter experimental cold pain 9
SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 17 28,523,380: 28,562,954 regulation of serotonergic signaling perception and modulation of pain; irritable bowel syndrome; headache
STX1A syntaxin 1A (brain)  7 73,113,534: 73,134,031 ion channel regulation and synaptic exocytosis migraine
TAOK3 TAO kinase 3 12 118,149,801: 118,372,945 kinase in the MAPK cascade postoperative pain
TSPAN2 (snp near) tetraspanin 2 1 115,590,631: 115,632,120 cell surface protein that mediates signal transduction events migraine
TGFB1 transforming growth factor, beta 1 19 41,836,811: 41,859,830  multifunctional cytokine TMD plus widespread tenderness
TRPA1 transient receptor potential cation channel, subfamily A, member 1 8 72,933,487: 72,987,819 nonselective cation channel that senses environmental irritants Familial episodic pain syndrome, somatosensory function 4
TRPM8 transient receptor potential cation channel, subfamily M, member 8 2 234,826,042: 234,928,165 calcium channel activated by cold and cooling compounds migraine
TRPV1 transient receptor potential cation channel, subfamily V, member 1 17 3,468,741: 3,500,336 nonselective cation channel that senses environmental irritants pain sensitivity and perception
TRPV3 transient receptor potential cation channel, subfamily V, member 3 17 3,413,795: 3,461,288 nonselective cational channel associated with temperature sensation headache
TNFA tumor necrosis factor 6 31,543,350: 31,546,110 multifunctional proinflammatory cytokine mainly secreted by macrophages painful neuropathy; migraine
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1 12,227,043: 12,269,278  tumor necrosis factor receptor migraine; diabetic neuropathy
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 4 69,955,189: 69,978,704 conjugation of potentially toxic xenobiotics and endogenous compounds including estrogens morphine analgesic response
CACNA2D3 voltage-dependent calcium channel, α2δ subunit 3 3 54,156,693: 55,108,582 regulates voltage-dependent calcium channels experimental thermal pain, chronic back pain 1
CACNG2 voltage-dependent calcium channel, γ subunit 2 22 36,960,104: 37,098,90 voltage-dependent calcium channel subunit chronic pain following nerve injury 1
WNK1 WNK lysine deficient protein kinase 1 12 862,225: 1,020,617 kinase; regulates ion transport Hereditary Sensory and Autonomic Neuropathy Type IIA (HSAN2A), cold pain sensitivity 12
ZNF429 zinc finger protein 429 19 21505635: 21538277 may be involved in transcriptional regulation postoperative analgesic onset
ADRA2C α2C adrenergic receptor 4 3,768,296: 3,770,251 adrenergic signaling angina, cold pain sensitivity 2
ADRB1 β1-adrenergic receptor 10 114,044,047: 114,046,908 adrenergic signaling cold pressor pain, analgesic sensitivity 1
ADRB2 β2-adrenergic receptor 5 148,206,156: 148,208,188 adrenergic signaling TMD, angina, fibromyalgia, chronic widespread pain 7

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