|
HTR1A |
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled |
5 |
63960048: 63962292 |
GPCR for serotonin |
thermal pain perception |
|
Summary: |
|
|
HTR2A |
5-hydroxytryptamine (serotonin) receptor 2A |
13 |
47,407,513: 47,470,369 |
receptor for the neurotransmitter serotonin |
musculoskeletal pain, irritable bowel syndrome, analgesia requirements, other |
13 |
Summary: |
|
|
HTR2C |
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled |
X |
114584078: 114910061 |
GPCR for serotonin |
analgesic response to escitalopram |
|
Summary: |
|
|
HTR3B |
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic |
11 |
113904796: 113946561 |
ionotropic receptor for serotonin |
pain castrophizing |
|
Summary: |
|
|
ARVCF |
armadillo repeat gene deleted in velocardiofacial syndrome |
22 |
19,966,603: 20,016,802 |
catenin family member that participates in formation of adherens junctions |
cold pressor pain |
1 |
Summary: |
|
|
ATL1 |
atlastin GTPase 1 |
14 |
50,069,550: 50,169,534 |
endoplasmic reticulum GTP-binding protein |
Hereditary Sensory and Autonomic Neuropathy Type ID |
1 |
Summary: |
|
|
ABCB1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
7 |
87,503,863: 87,713,323 |
ATP-dependent drug efflux pump |
opioid response, chemotherapy-induced neuropathy |
28 |
Summary: |
|
|
BDNF |
brain-derived neurotrophic factor |
11 |
27,654,893: 27,722,058 |
neuron growth and survival factor; major regulator of synaptic transmission and plasticity in adults |
migraine, cortical pain processing, primary dysmenorrhea |
10 |
Summary: |
|
|
CACNA1E |
calcium channel, voltage-dependent, R type, alpha 1E subunit |
1 |
181,483,550: 181,806,784 |
R-type ('high-voltage activated' ) calcium channel subunit |
fentanyl sensitivity |
|
Summary: |
|
|
CSNK1D |
casein kinase 1, delta |
17 |
80,197,522: 80,231,593 |
serine/threonine specific protein kinase |
migraine |
|
Summary: |
|
|
COMT |
catechol-O-methyltransferase |
22 |
19,929,263: 19,957,496 |
neurotransmitter degradation |
various |
|
Summary: |
Text to come. |
|
CCT5 |
chaperonin-containing TCP1, subunit 5 (epsilon) |
5 |
10,250,282: 10,266,500 |
molecular chaperone |
sensory neuropathy |
1 |
Summary: |
Text to come. |
|
CRHBP |
corticotropin releasing hormone binding protein |
5 |
76,952,855: 76,969,474 |
inactivates corticotropin-releasing hormone |
more pain sites in chronic widespread pain |
|
Summary: |
|
|
CYP2D6 |
cytochrome p450, family 2, subfamily D, polypeptide 6 |
22 |
42,522,502: 42,526,883 |
monooxygenase |
opioid response |
|
Summary: |
Text to come. |
|
DNMT1 |
DNA (cytosine-5-)-methyltransferase-1 |
19 |
10,244,023:10,305,755 |
controls gene expression through DNA methylation |
Hereditary sensory and autonomic neuropathy type I with dementia and hearing loss (HSAN IE) |
1 |
Summary: |
Text to come. |
|
EDNRA |
endothelin receptor type A |
4 |
147,480,917: 147,544,954 |
GPCR that mediates effects of endothelin-1 in vasoconstriction |
migraine |
|
Summary: |
|
|
ESR1 |
estrogen receptor 1 |
6 |
152,128,454: 152,424,406 |
nuclear estrogen receptor |
migraine, dysmenorrhea, osteoarthritis pain |
13 |
Summary: |
|
|
MEFV |
Familal Mediterranean fever gene |
16 |
3,292,028: 3,306,627 |
modulator of innate immunity |
fibromyalgia, dysmenorrhea |
3 |
Summary: |
|
|
FAM134B |
family with sequence similarity 134, member B |
5 |
16,473,148: 16,617,118 |
Required for long-term survival of nociceptive and autonomic ganglion neurons |
Hereditary Sensory and Autonomic Neuropathy Type IIB (HSAN2B) |
3 |
Summary: |
|
|
FAAH |
fatty acid amide hydrolase |
1 |
46,859,939: 46,879,520 |
inactivates the endocannabinoid anandamide |
experimental cold pain, functional GI disorders, Parkinson disease |
3 |
Summary: |
Text to come. |
|
GCH1 |
GTP cyclohydrolase 1 |
14 |
55,308,724: 55,369,542 |
rate-limiting enzyme for BH4 synthesis |
acute and chronic pain, experimental pain |
13 |
Summary: |
|
|
HCRTR2 |
hypocretin (orexin) receptor 2 |
6 |
55,106,460: 5,5282,620 |
GPCR that regulates feeding behavior and sleep |
cluster headache |
|
Summary: |
|
|
IKBKAP |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein |
9 |
111,629,801: 111,696,608 |
scaffold protein and regulator of proinflammatory signaling |
Hereditary Sensory and Autonomic Neuropathy Type III (HSAN3) or Familial Dysautonomia |
3 |
Summary: |
|
|
IL1RN |
interleukin 1 receptor antagonist |
2 |
113,885,138: 113,891,592 |
inhibits the activity of IL-1 |
postoperative opioid use, lower back pain, vulvar vestibulitis |
8 |
Summary: |
|
|
IL1R1 |
interleukin 1 receptor, type I |
2 |
102,686,835: 102,796,333 |
cytokine receptor for interleukin 1 |
breast pain in women with breast cancer |
1 |
Summary: |
|
|
IL1R2 |
interleukin 1 receptor, type II |
2 |
102,608,305: 102,644,884 |
cytokine receptor for interleukin 1 |
postsurgical pain |
1 |
Summary: |
|
|
IL1A |
interleukin 1, alpha |
2 |
113,531,493: 113,542,971 |
cytokine produced by activated machrophages and involved in the inflammatory response |
low back pain |
2 |
Summary: |
|
|
IL1B |
interleukin 1, beta |
2 |
113,531,493: 113,542,971 |
cytokine produced by activated machrophages and involved in the inflammatory response |
low back pain, burning mouth syndrome, migraine, vulvar vestibulitis |
5 |
Summary: |
|
|
IL10 |
Interleukin 10 |
4 |
74,606,275: 74,609,431 |
inhibits the synthesis of a number of cytokines |
postsurgical pain; irritable bowel syndrome; pelvic pain, diabetic peripheral neuropathy |
10 |
Summary: |
Ates et al., 2011 report no association of IL10 polymorphisms or haplotypes with migraines. Reyes-Gibby et al., 2009 (PMID: 19692203) found no associations with pain severity in adenocarcinoma of the pancreas. No differences in genotype with regard to pain in juvenile rheumatoid arthrtis seen in Oen et al., 2005. |
|
IL13 |
interleukin 13 |
5 |
131,993,864: 131,996,800 |
anti-inflammatory cytokine |
breast pain in women with breast cancer |
1 |
Summary: |
|
|
IL16 |
interleukin 16 (lymphocyte chemoattractant factor) |
15 |
81,489,219: 81,605,101 |
stimulates migratory response in inflammatory cells |
|
1 |
Summary: |
|
|
IL6 |
interleukin 6 |
7 |
22,766,766: 22,771,619 |
cytokine involved in inflammatory response |
pain in lung cancer, arthritis; irritable bowel syndrome; sciatica |
7 |
Summary: |
|
|
IL8 |
interleukin 8 |
4 |
74,606,275: 74,609,431 |
proinflammatory cytokine |
cancer pain, temporomandibular disorder |
4 |
Summary: |
|
|
KIF1A |
kinesin family member 1A |
2 |
241,653,181: 241,759,725 |
motor for axonal transport of synaptic vesicles |
Hereditary Sensory and Autonomic Neuropathy Type IIC (HSN2C) |
1 |
Summary: |
|
|
LRP1 |
low density lipoprotein receptor-related protein 1 |
12 |
57,522,281:57,607,141 |
endocytic receptor |
migraine |
|
Summary: |
|
|
HLA-B |
major histocompatibility complex, class I, B |
6 |
31,321,649: 31,324,989 |
involved in the presentation of foreign antigens to the immune system |
CRPS; postherpetic neuralgia |
|
Summary: |
|
|
HLA-DQ |
major histocompatibility complex, class II |
6 |
32,605,183: 32,611,428 |
involved in the presentation of foreign antigens to the immune system |
CRPS; chronic postsurgical pain |
|
Summary: |
|
|
MC1R |
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
16 |
89,984,287: 89,987,385 |
controls melanogenesis |
pain and analgesia, fear of dental pain, vuvlar vestibulitis |
6 |
Summary: |
|
|
MTDH |
metadherin |
8 |
98,656,374: 98,742,487 |
transcriptional coactivator |
migraine |
|
Summary: |
|
|
MAOA |
monoamine oxidase A |
X |
43,515,409: 43,606,067 |
catalyzes the oxidation and degradation of monoamine neurotransmitters |
postoperative pain, cold pain tolerance, migraine |
12 |
Summary: |
|
|
MAOB |
monoamine oxidase B |
X |
43,625,858: 43,741,721 |
catalyze the oxidation and degradation of monoamine neurotransmitters |
acute postsurgical pain |
1 |
Summary: |
|
|
MYT1L |
myelin transcription factor 1-like |
2 |
1,792,884: 2,335,146 |
neural lineage-specific transcription factor |
fibromyalgia |
|
Summary: |
|
|
ATP1A2 |
Na+/K+ ATPase, α2 subunit |
1 |
160,085,520: 160,113,372 |
Na+/K+ ATPase catalytic subunit |
migraine |
35 |
Summary: |
|
|
NGFB |
nerve growth factor (beta polypeptide) |
1 |
115,828,537:115,880,857 |
neurotrophic growth factor |
congenital insensitivity to pain (Hereditary Sensory and Autonomic Neuropathy type V, HSAN5) |
5 |
Summary: |
|
|
NRXN3 |
neurexin 3 |
14 |
78,636,715: 80,334,632 |
neuronal cell surrface protein that may be involved in cell recognition and adhesion |
fibromyalgia |
|
Summary: |
|
|
NTRK1 |
neurotrophic tyrosine kinase, receptor, type 1 |
1 |
156,830,671: 156,851,642 |
receptor tyrosine kinase for nerve growth factor |
congenital insensitivity to pain with anhidrosis (CIPA); hereditary and sensory autonomic neuropathy type IV (HSAN4) |
18 |
Summary: |
|
|
NOS3 |
nitric oxide synthase 3 (endothelial cell) |
7 |
150,688,144: 150,711,686 |
involved in nitric oxide synthesis |
migraine |
|
Summary: |
|
|
NFKB1A |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
14 |
35,870,717: 35,873,960 |
inhibits the activity of NF-Kappa-B complexes |
pain in lung cancer patients |
|
Summary: |
|
|
OPRD1 |
opioid receptor, delta 1 |
1 |
29,138,654: 29,190,208 |
receptor for opioids |
acute pain senstivity; response to opioids |
|
Summary: |
|
|
OPRM1 |
opioid receptor, mu 1 |
6 |
154,360,443: 154,414,655 |
receptor for opioids |
response to opioids |
|
Summary: |
|
|
CACNA1A |
P/Q-type voltage gated calcium channel, α1a subunit |
19 |
13,317,256: 13,617,274 |
P/Q-type calcium channel subunit |
migraine |
24 |
Summary: |
Text to come. |
|
KCNN3 |
potassium channel, calcium-activated, intermediate/small conductance, subfamily N, member 3 |
1 |
154,669,937: 154,842,753 |
voltage-independent calcium-activated channel thought to regulate neuronal excitability |
migraine |
|
Summary: |
|
|
KCNJ3 |
POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 3 |
2 |
155,555,092: 155,714,863 |
GPCR-regulated potassium channel GIRK1 |
breast pain in women with breast cancer |
|
Summary: |
|
|
KCNK18 |
potassium channel, subfamily K, member 18 |
10 |
118,957,000: 118,969,809 |
two-pore domain (K2P) potassium channel |
familial migraine with aura |
1 |
Summary: |
|
|
KCNK9 |
POTASSIUM CHANNEL, SUBFAMILY K, MEMBER 9 |
8 |
140,613,080: 140,715,298 |
pH-dependent potassium channel |
breast pain in women with breast cancer |
|
Summary: |
|
|
KCNJ6 |
potassium inwardly-rectifying channel, subfamily J, member 6 |
21 |
38,996,786: 39,288,696 |
potassium channel that regulates insulin secretion by glucose and neurotransmitters |
postoperative analgesic use, breast cancer pain, chronic pain, methadone use |
4 |
Summary: |
|
|
KCNS1 |
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1; Kv9.1 |
20 |
43720951: 43729753 |
voltage-gated potassium channel subunit |
pain after nerve injury, experimental pain sensitivity |
1 |
Summary: |
|
|
PRDM16 |
PR domain containing 16 |
1 |
2,985,564: 3,355,184 |
zinc finger transcription factor |
migraine |
|
Summary: |
|
|
PRRT2 |
proline-rich transmembrane protein 2 |
16 |
29,823,408: 29,827,201 |
transmembrane protein mutated in dyskinesias convulsion and seizure disorders |
migraine |
|
Summary: |
|
|
POMC |
proopiomelanocortin |
2 |
25,383,721: 25,391,558 |
precurosr of beta-endorphin and met-enkephalin |
chronic widespread pain |
|
Summary: |
|
|
PTGS2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); COX2 |
1 |
186,640,945: 186,649,559 |
mediates the formation of prostaglandins |
pain in lung cancer patients; migraine |
|
Summary: |
|
|
RAB7A |
RAB7A, member RAS oncogene family |
3 |
128,444,974: 128,533,640 |
regulator of vesicular transport |
Hereditary motor and sensory neuropathy IIB |
|
Summary: |
|
|
RHBDF2 |
rhomboid 5 homolog 2 (Drosophila) |
17 |
74,466,974: 74,497,508 |
inhibits EGF and TNF release |
opioid response |
|
Summary: |
|
|
SEPT9 |
septin 9 |
17 |
75,277,492: 75,496,676 |
involved in cytokinesis and cell cycle control |
Hereditary neuralgic amyotrophy |
|
Summary: |
|
|
SPTLC1 |
serine palmitoyltransferase, long chain base subunit 1 |
9 |
94,793,427: 94,877,690 |
a subunit of a key enzyme in sphingolipid biosynthesis |
Hereditary Sensory and Autonomic Neuropathy Type IA (HSAN1A) |
10 |
Summary: |
|
|
SPTLC2 |
serine palmitoyltransferase, long chain base subunit 2 |
14 |
77,973,272: 78,083,110 |
a subunit of a key enzyme in sphingolipid biosynthesis |
Hereditary Sensory and Autonomic Neuropathy Type IC (HSAN1C) |
2 |
Summary: |
|
|
SERPINA6 |
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 |
14 |
94,770,584: 94,789,687 |
serine protease inhibitor; major transport protein for glucocorticoids and progestins in blood |
chronic widespread pain |
|
Summary: |
|
|
SCN4A |
sodium channel, voltage gated, type IV alpha subunit |
17 |
62,015,913: 62,066,875 |
Nav1.4 voltage-gated sodium channel subunit |
oxaliplatin-induced peripheral neuropathy; painful cold-induced myotonia |
|
Summary: |
|
|
SCN1A |
sodium channel, voltage-gated, type I, alpha subunit |
2 |
166845671: 166930149 |
mediates the voltage-dependent sodium ion permeability of excitable membranes |
familial hemiplegic migraine |
|
Summary: |
Data annotation in progress. |
|
SCN2A |
sodium channel, voltage-gated, type II, alpha subunit |
2 |
166,152,283: 166,248,818 |
voltage-gated sodium channel subunit |
oxaliplatin-induced peripheral neuropathy |
|
Summary: |
|
|
SCN9A |
sodium channel, voltage-gated, type IX, alpha subunit |
2 |
167,051,704: 167,232,497 |
voltage-gated sodium channel Nav1.7 subunit |
erythermalgia, PEPD, CIP, pain sensitivity |
47 |
Summary: |
|
|
SCN10A |
sodium channel, voltage-gated, type X, alpha subunit |
3 |
38,738,836: 38,835,500 |
voltage-gated sodium channel Nav1.8 subunit |
familial episodic pain 2 (FEPS2) |
2 |
Summary: |
|
|
SCN11A |
sodium channel, voltage-gated, type XI, alpha subunit |
3 |
38,887,259: 38,995,135 |
voltage-gated sodium channel Nav1.9 subunit |
congenital insensitivity to pain; familial episodic pain; small fiber neuropathy |
3 |
Summary: |
|
|
SLC2A1 |
solute carrier family 2 (facilitated glucose transporter), member 1 |
1 |
43,391,045: 43,424,846 |
major glucose transporter in the blood-brain barrier |
hemiplegic migraine |
|
Summary: |
|
|
SLC6A3 |
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; DAT-1 |
5 |
1,392,910: 1,445,538 |
dopamine transporter |
experimental cold pain |
9 |
Summary: |
Text to come. |
|
SLC6A4 |
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 |
17 |
28,523,380: 28,562,954 |
regulation of serotonergic signaling |
perception and modulation of pain; irritable bowel syndrome; headache |
|
Summary: |
|
|
STX1A |
syntaxin 1A (brain) |
7 |
73,113,534: 73,134,031 |
ion channel regulation and synaptic exocytosis |
migraine |
|
Summary: |
|
|
TAOK3 |
TAO kinase 3 |
12 |
118,149,801: 118,372,945 |
kinase in the MAPK cascade |
postoperative pain |
|
Summary: |
|
|
TSPAN2 (snp near) |
tetraspanin 2 |
1 |
115,590,631: 115,632,120 |
cell surface protein that mediates signal transduction events |
migraine |
|
Summary: |
|
|
TGFB1 |
transforming growth factor, beta 1 |
19 |
41,836,811: 41,859,830 |
multifunctional cytokine |
TMD plus widespread tenderness |
|
Summary: |
|
|
TRPA1 |
transient receptor potential cation channel, subfamily A, member 1 |
8 |
72,933,487: 72,987,819 |
nonselective cation channel that senses environmental irritants |
Familial episodic pain syndrome, somatosensory function |
4 |
Summary: |
|
|
TRPM8 |
transient receptor potential cation channel, subfamily M, member 8 |
2 |
234,826,042: 234,928,165 |
calcium channel activated by cold and cooling compounds |
migraine |
|
Summary: |
|
|
TRPV1 |
transient receptor potential cation channel, subfamily V, member 1 |
17 |
3,468,741: 3,500,336 |
nonselective cation channel that senses environmental irritants |
pain sensitivity and perception |
|
Summary: |
|
|
TRPV3 |
transient receptor potential cation channel, subfamily V, member 3 |
17 |
3,413,795: 3,461,288 |
nonselective cational channel associated with temperature sensation |
headache |
|
Summary: |
|
|
TNFA |
tumor necrosis factor |
6 |
31,543,350: 31,546,110 |
multifunctional proinflammatory cytokine mainly secreted by macrophages |
painful neuropathy; migraine |
|
Summary: |
|
|
TNFRSF1B |
tumor necrosis factor receptor superfamily, member 1B |
1 |
12,227,043: 12,269,278 |
tumor necrosis factor receptor |
migraine; diabetic neuropathy |
|
Summary: |
|
|
UGT2B7 |
UDP glucuronosyltransferase 2 family, polypeptide B7 |
4 |
69,955,189: 69,978,704 |
conjugation of potentially toxic xenobiotics and endogenous compounds including estrogens |
morphine analgesic response |
|
Summary: |
|
|
CACNA2D3 |
voltage-dependent calcium channel, α2δ subunit 3 |
3 |
54,156,693: 55,108,582 |
regulates voltage-dependent calcium channels |
experimental thermal pain, chronic back pain |
1 |
Summary: |
Text to come. |
|
CACNG2 |
voltage-dependent calcium channel, γ subunit 2 |
22 |
36,960,104: 37,098,90 |
voltage-dependent calcium channel subunit |
chronic pain following nerve injury |
1 |
Summary: |
Text to come. |
|
WNK1 |
WNK lysine deficient protein kinase 1 |
12 |
862,225: 1,020,617 |
kinase; regulates ion transport |
Hereditary Sensory and Autonomic Neuropathy Type IIA (HSAN2A), cold pain sensitivity |
12 |
Summary: |
|
|
ZNF429 |
zinc finger protein 429 |
19 |
21505635: 21538277 |
may be involved in transcriptional regulation |
postoperative analgesic onset |
|
Summary: |
|
|
ADRA2C |
α2C adrenergic receptor |
4 |
3,768,296: 3,770,251 |
adrenergic signaling |
angina, cold pain sensitivity |
2 |
Summary: |
Text to come |
|
ADRB1 |
β1-adrenergic receptor |
10 |
114,044,047: 114,046,908 |
adrenergic signaling |
cold pressor pain, analgesic sensitivity |
1 |
Summary: |
|
|
ADRB2 |
β2-adrenergic receptor |
5 |
148,206,156: 148,208,188 |
adrenergic signaling |
TMD, angina, fibromyalgia, chronic widespread pain |
7 |
Summary: |
Text to come. |