ADRB2

Gene Name:

β2-adrenergic receptor

Synonyms:

adrenergic, beta-2-, receptor, surface; Beta-2 adrenoreceptor; BAR; Beta-2 adrenoceptor

Chromosome:

5

Chromosomal Location:

148,206,156: 148,208,188

Entrez Gene ID:

154

OMIM ID:

109690

Protein Name:

beta-2 adrenergic receptor

UNIPROT ID:

P07550

Function:

adrenergic signaling

Phenotype/Disease:

TMD, angina, fibromyalgia, chronic widespread pain

Pain Data in Humans:

ADRB2-v1

Variant Type:

common polymorphisms

Variant ID:

H1, H2, H3 haplotypes

Phenotype/Disease:

temporomandibular joint disorder (TMD)

Reference(s):

Diatchenko et al., 2006

Notes:

The risk for developing TMD was increased in people homozygous for low (H1) or high (H2, H3) expressing haplotypes, but decreased in high/low heterozygotes.

ADRB2-v2

Variant Type:

common polymorphism

Phenotype/Disease:

vasospastic angina

SNP ID:

rs1042714

SNP Type:

missense

Minor Allele:

G (Glu27)

Phenotype of Minor Allele:

lower risk of vasospastic angina

Reference(s):

Park et al., 2006

Notes:

Park et al. also tested rs1042713 and found no association.

ADRB2-v3

Variant Type:

common polymorphism

Phenotype/Disease:

chronic widespread pain, pain status, fibromyalgia

SNP ID:

rs1042713

SNP Type:

missense

Minor Allele:

A (Arg16)

Phenotype of Minor Allele:

reduced risk of CWP, trend towards reduced risk of FM

Reference(s):

Hocking et al., 2010

Xiao et al., 2011

Notes:

Xiao et al. report decreased heterozygosity in fibromyalgia group, and a trend toward lower risk with A allele. Hocking et al. was negative for association with 7 other SNPs in ADRB2 and 11 SNPs in COMT.

adrb2-v4

Variant Type:

common polymorphism

Phenotype/Disease:

chronic widespread pain, pain status

SNP ID:

rs12654778

SNP Type:

5' noncoding

Minor Allele:

A (Arg16)

Phenotype of Minor Allele:

reduced risk of CWP

Reference(s):

Hocking et al., 2010

Notes:

Study was negative for association with 7 other SNPs in ADRB2 and 11 SNPs in COMT.

ADRB2-v7

Variant Type:

common polymorphism

Phenotype/Disease:

chronic, disabling comorbind neck and low back pain in adolescents

SNP ID:

rs2053044

SNP Type:

5' noncoding

Minor Allele:

A

Phenotype of Minor Allele:

greater risk of pain

Reference(s):

Skouen et al., 2012

Notes:

Study was negative for 4 other SNPs in ADRB2 and 8 in COMT.

ADRB2-v5

Variant Type:

common polymorphisms

Variant ID:

AC haplotype: Arg16 (rs1042713, A allele)/Gln27 (rs1042714, C allele)

Phenotype/Disease:

Fibromyalgia in women

Reference(s):

Vargas-Alarcón et al., 2009

Notes:

Haplotype was associated with increased risk of FM in Spanish and Mexican women.

ADRB2-v6

Variant Type:

common polymorphisms

Phenotype/Disease:

migraine in women

SNP ID:

rs1042713, rs1042713, rs1800888

SNP Type:

missense

Minor Allele:

G (Glu27), A (Arg16), T (Ile164)

Reference(s):

Schürks et al., 2009

Notes:

Negative result: No association with migraine in women.

Pain Research Forum

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