KCNJ6

Gene Name:

potassium inwardly-rectifying channel, subfamily J, member 6

Synonyms:

GIRK2; BIR1; KATP2; KIR3.2; KCNJ7 (FORMERLY)

Chromosome:

21

Chromosomal Location:

38,996,786: 39,288,696

Entrez Gene ID:

3763

OMIM ID:

600877

Protein Name:

G protein-activated inward rectifier potassium channel 2

UNIPROT ID:

P48051

Function:

potassium channel that regulates insulin secretion by glucose and neurotransmitters

Phenotype/Disease:

postoperative analgesic use, breast cancer pain, chronic pain, methadone use

Pain Data in Humans:

KCNJ6-v1

Variant Type:

common polymorphisms

Phenotype/Disease:

postoperative opioid use

SNP ID:

rs6517442, rs2070995

SNP Type:

5' near gene, synonymous coding

Minor Allele:

C, T

Phenotype of Minor Allele:

Increased postoperative analgesic requirements in AA genotype of rs2070995 and in GA haplotype

Reference(s):

Nishizawa et al., 2009

Notes:

KCNJ6 gene expression levels in AA subjects significantly decreased compared to AG and GG subjects, suggesting that AA subjects needed more analgesic because of lower KCNJ6 gene expression levels and thus insufficient analgesic effects.

KCNJ6-v2

Variant Type:

common polymorphism

Phenotype/Disease:

methadone use in former heroin addicts, chronic pain

SNP ID:

rs2070995

SNP Type:

synonymous coding

Minor Allele:

T

Phenotype of Minor Allele:

Increased daily methadone substitution doses in AA genotype, lack of opioid withdrawal symptoms, higher analgesia dosing demands

Reference(s):

Lötsch et al., 2010

KCNJ6-v3

Variant Type:

common polymorphisms

Phenotype/Disease:

postoperative analgesic use, acute pain tolerance, pain intensity and unpleasantness

SNP ID:

8 different KCNJ6 snps

Phenotype of Minor Allele:

8 snps (of 69 tested) significantly associated with amount of medication ordered after knee arthroplasty

Reference(s):

Bruehl et al., 2013

Notes:

Using the 8 significant snps, Bruehl et al. derived a GIRK-related risk score based on number of alleles carried. This score was significanlty associated with lower acute (ischemic) pain tolerance in healthy subjects and higher pain intensity and unpleasantness in chronic low back pain patients.

KCNJ6-v5

Variant Type:

common polymorphism

Phenotype/Disease:

preoperative breast pain in patients scheduled for breast cancer surgery

SNP ID:

rs2836050

SNP Type:

intronic

Minor Allele:

T

Phenotype of Minor Allele:

increased odds of reporting preoperative breast pain

Reference(s):

Langford et al., 2014

KCNJ6-v4

Variant Type:

common polymorphisms

Phenotype/Disease:

preoperative breast pain in patients scheduled for breast cancer surgery

SNP ID:

rs2835914, rs8129919

SNP Type:

intronic

Minor Allele:

C, G

Phenotype of Minor Allele:

decreased odds of reporting preoperative breast pain

Reference(s):

Langford et al., 2014

Notes:

Negative results in the same study: A total of 48 snps in other potassium channel genes KCNA1, KCND2, KCNJ5, KCNJ9, KCNK2, KCNJ3.

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