IL6

Gene Name:

interleukin 6

Chromosome:

7

Chromosomal Location:

22,766,766: 22,771,619

Entrez Gene ID:

3569

OMIM ID:

147620

Protein Name:

interleukin-6 (IL-6)

UNIPROT ID:

P0523

Function:

cytokine involved in inflammatory response

Phenotype/Disease:

pain in lung cancer, arthritis; irritable bowel syndrome; sciatica

Pain Data in Humans:

il6-v1

Variant Type:

common polymorphism

Variant ID:

-174G>C

Phenotype/Disease:

pain in lung cancer, pain in juvenile rheumatoid arthritis(RA), irritable bowel syndrome (IBS)

SNP ID:

rs1800795

SNP Type:

5' upstream

Minor Allele:

C

Phenotype of Minor Allele:

Higher pain severity in women, higher morphine equivalent daily dose (MEDD) in men and women with lung cancer; negative correlation with pain in juvenile RA; lower risk of IBS

Reference(s):

Reyes-Gibby et al., 2008

Oen et al., 2005

Barkhordari et al., 2010

Notes:

The rs1800795 is a functional polymorphism affecting IL6 gene transcription, and the minor allele is associated with significantly lower levels of plasma IL-6 (Fishman et al., 1998).

Barkhordari et al., 2010 report no association with irritable bowel syndrome for a second, intronic SNP (nt565, SNP number not given), but did see overrepresenation of a two-SNP haplotype in patient group.

Negative results: A previous study on pain in lung cancer (Reyes-Gibby et al., 2007) found no significant associations, possibly due to small sample sizes. Rainero et al., 2003 reported no significant association with migraine.

il6-v2

Variant Type:

common polymorphism

Phenotype/Disease:

intervertebral disc disease characterized by sciatica

SNP ID:

rs13306435

SNP Type:

missense

Minor Allele:

A

Phenotype of Minor Allele:

increased risk of disease

Reference(s):

Noponen-Hietala et al., 2005

IL6-v3

Variant Type:

haplotype

Variant ID:

GGGA haplotype

Phenotype/Disease:

intervertebral disc disease characterized by sciatica

SNP ID:

rs1800795, rs1800796, rs1800797, rs13306435

SNP Type:

promoter, promoter, promoter, missense

Minor Allele:

C, C, A, A

Phenotype of Minor Allele:

haploptype predicts worse progosis: more days with back and leg pain, more days on sick leave

Reference(s):

Karppinen et al., 2008

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IL6

il6-v1

il6-v2

IL6-v3

Research Resources

The IASP Pain Research Forum is a publication of the International Association for the Study of Pain