FAAH

Gene Name:

fatty acid amide hydrolase

Synonyms:

FAAH-1; EC 3.5.1.99; Anandamide amidohydrolase 1; FAAH1

Chromosome:

1

Chromosomal Location:

46,859,939: 46,879,520

Entrez Gene ID:

2166

OMIM ID:

602934

Protein Name:

fatty acid amide hydrolase

UNIPROT ID:

O00519

Function:

inactivates the endocannabinoid anandamide

Phenotype/Disease:

experimental cold pain, functional GI disorders, Parkinson disease

Pain Data in Humans:

FAAH-v1

Variant Type:

common polymorphism

Phenotype/Disease:

experimental cold pain

SNP ID:

rs932816

SNP Type:

5' non-coding

Minor Allele:

A

Phenotype of Minor Allele:

increased cold pain intensity in men

Reference(s):

Kim et al., 2006

Notes:

Kim et al. tested 7 SNPs in FAAH; three showed signficant associations in men. This SNP was negative for assocation with Parkinson disease-related pain in Greenbaum et al., 2012.

FAAH-v2

Variant Type:

common polymorphism

Phenotype/Disease:

experimental cold pain

SNP ID:

rs4141964

SNP Type:

intronic

Minor Allele:

A

Phenotype of Minor Allele:

increased cold pain intensity, decreased withdrawal time in men

Reference(s):

Kim et al., 2006

Notes:

Kim et al. tested 7 SNPs in FAAH; three showed signficant associations in men.

FAAH-v3

Variant Type:

common polymorphism

Phenotype/Disease:

experimental cold pain

SNP ID:

rs2295633

SNP Type:

intronic

Minor Allele:

T

Phenotype of Minor Allele:

increased cold pain intensity in men

Reference(s):

Kim et al., 2006

Notes:

Kim et al. tested 7 SNPs in FAAH; three showed signficant associations in men. This SNP was negative for assocation with Parkinson disease-related pain in Greenbaum et al., 2012.

FAAH-v4

Variant Type:

common polymorphism

Variant ID:

P129T

Phenotype/Disease:

functional gastrointestinal disorders

SNP ID:

rs324420

SNP Type:

missense

Minor Allele:

A

Phenotype of Minor Allele:

higher risk of disorder

Reference(s):

Camilleri et al., 2008

Notes:

Significant association with overall phenotype but not pain or sensation phenotypes.

FAAH-v5

Variant Type:

common polymorphism

Phenotype/Disease:

pain in Parkinson disease

SNP ID:

rs324419

SNP Type:

synonymous

Minor Allele:

A

Phenotype of Minor Allele:

increased risk of musculoskeletal pain

Reference(s):

Greenbaum et al., 2012

Notes:

This SNP was negative in Kim et al. 2006 study of experimental cold pain.

FAAH-v6

Variant Type:

haplotype

Phenotype/Disease:

pain in Parkinson disease

SNP ID:

rs324419, rs2295633

SNP Type:

synonymous, intronic

Minor Allele:

A,T

Phenotype of Minor Allele:

increased risk of musculoskeletal pain

Reference(s):

Greenbaum et al., 2012

Pain Research Forum

Progress through collaboration

Utility Navigation

User Top Menu

Main menu

FAAH-v1

FAAH-v2

FAAH-v3

FAAH-v4

FAAH-v5

FAAH-v6

Research Resources

Pain Research Forum

Progress through collaboration

Utility Navigation

User Top Menu

Main menu

Search form

You are here

FAAH

FAAH-v1

FAAH-v2

FAAH-v3

FAAH-v4

FAAH-v5

FAAH-v6

Research Resources

The IASP Pain Research Forum is a publication of the International Association for the Study of Pain