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Ru-Rong Ji, Duke University Medical Center
This is an interesting paper,
This is an interesting paper, which demonstrates a role for the Wnt signaling pathway in chronic pain conditions. It also demonstrates that inhibiting Wnt signaling reduced neuropathic and cancer pain in rodents. The amount of data is very impressive. The underlying molecular mechanisms remain to be identified. It is also unclear whether the neurochemical changes were directly or indirectly induced by Wnt signaling. Given an important role of Wnt signaling in cell growth, targeting this pathway may have side effects in healthy subjects. Targeting this pathway could be particularly useful in cancer patients where both tumor growth and pain can be modified by Wnt signaling.