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Papers of the Week
IL-37 alleviates intervertebral disc degeneration via the IL-1R8/NF-κB pathway.
Authors
Abstract
Intervertebral disc degeneration (IDD) has been reported to be a major cause of low back pain. Interleukin (IL)-37 is an anti-inflammatory cytokine of the interleukin-1 family, which exerts salutary physiological effects. In this study, we assessed the protective effect of IL-37 on IDD progression and its underlying mechanisms.