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Papers of the Week


Papers: 14 Jan 2023 - 20 Jan 2023


Pharmacology/Drug Development


2023 Jan 16


Eur J Pharmacol

Inhibition of TRPM8 by the urinary tract analgesic drug phenazopyridine.

Authors

Luyts N, Daniluk J, Freitas A, Bazeli B, Janssens A, Mulier M, Everaerts W, Voets T
Eur J Pharmacol. 2023 Jan 16:175512.
PMID: 36657655.

Abstract

and purpose: Phenazopyridine (PAP) is an over-the-counter drug widely used to provide symptomatic relief of bladder pain in conditions such as cystitis or bladder pain syndrome (BPS). Whereas the analgesic effect of PAP has been attributed to a local effect on the mucosa of the lower urinary tract (LUT), the molecular targets of PAP remain unknown. We investigated the effect of PAP on pain-related Transient Receptor Potential (TRP) channels expressed in sensory neurons that innervate the bladder wall.