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Papers of the Week


Papers: 10 Sep 2022 - 16 Sep 2022


Pharmacology/Drug Development


2022 Sep-Oct


In Vivo


36


5

Effect of Systemic Administration of Amitriptyline on Oral Microbes in Rats.

Authors

Ninomiya K, Paudel D, Uehara O, Morikawa T, Islam S T, Khurelchuluun A, Ariwansa D, Yoshida K, Matsuoka H, Hajime H, Kayoko F, Nakamura K, Abiko Y
In Vivo. 2022 Sep-Oct; 36(5):2134-2142.
PMID: 36099099.

Abstract

Amitriptyline is a major tricyclic antidepressant that is also used to relieve chronic orofacial pain. Recently, alterations in gut flora due to various antidepressants have been demonstrated. However, it remains unknown how antidepressants affect the oral environment, including microbiota and innate immunity. The aim of this study was to investigate the effects of amitriptyline on oral microflora and antimicrobial peptides.