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Papers of the Week


Papers: 20 Aug 2022 - 26 Aug 2022


Animal Studies


2022 Aug 12


BMC Res Notes


15


1

The therapeutic effects of autologous conditioned serum on knee osteoarthritis: an animal model.

Authors

Pishgahi A, Zamani M, Mehdizadeh A, Roshangar L, Afkham-Daghdaghan M, Pourabbas B, Yousefi M
BMC Res Notes. 2022 Aug 12; 15(1):277.
PMID: 35962413.

Abstract

As a progressive chronic condition, osteoarthritis (OA) causes substantial pain and impairment. Secrete proinflammatory cytokines are essential mediators involved in the pathophysiology of OA. In this regard, the clinical effectiveness of autologous conditioned serum (ASC) has been shown through its injection into OA tissues. This study aimed to assess the effectiveness and concentration level of ACS components produced by Nano-carbon glass beads. Intravenous whole blood was obtained from each New Zealand male rabbit by 10-ml syringes, comprising 33 medical-grade Nano carbon-coated glass beads. Serum retrieving was performed after 6-8 h incubation (37 C, 5% Co), and then centrifuged. The ACS was then injected into OA rabbits to assess its function.