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Papers of the Week


Papers: 20 Aug 2022 - 26 Aug 2022


Pharmacology/Drug Development


2022 Aug 11


Mol Imaging Biol

Radiosynthesis and Evaluation of a C-11 Radiotracer for Transient Receptor Potential Canonical 5 in the Brain.

Authors

Yu Y, Jiang H, Liang Q, Qiu L, Huang T, Hu H, Bolshakov VY, Perlmutter JS, Tu Z
Mol Imaging Biol. 2022 Aug 11.
PMID: 35951211.

Abstract

TRPC5 belongs to the mammalian superfamily of transient receptor potential (TRP) Ca-permeable cationic channels and it has been implicated in various CNS disorders. As part of our ongoing interest in the development of a PET radiotracer for imaging TRPC5, herein, we explored the radiosynthesis, and in vitro and in vivo evaluation of a new C-11 radiotracer [C]HC070 in rodents and nonhuman primates.