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Papers of the Week


Papers: 6 Aug 2022 - 12 Aug 2022


Animal Studies, Pharmacology/Drug Development


2022 Aug 04


Gastroenterology

Editor's Pick

Gut Microbiota Alter Visceral Pain Sensation and Inflammation via Modulation of Synthesis of Resolvin D1 in Colonic Tuft Cells.

Authors

Grabauskas G, Gao J, Wu X, Zhou S-Y, Turgeon DK, Owyang C
Gastroenterology. 2022 Aug 04.
PMID: 35934059.

Abstract

Visceral hypersensitivity and low grade mucosal inflammation are frequently observed in a subpopulation of irritable bowel syndrome (IBS) patients. The responsible mechanism is unclear. Resolvins are a novel class of anti-inflammatory lipid mediators that regulate resolution of inflammation and pain. We hypothesize that resolvin D1 (RvD1) synthesis is reduced in IBS-D colonic mucosa and contribute to the development of visceral hypersensitivity.