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Papers of the Week
Evaluation of the Anti-Inflammatory and Chondroprotective Effect of Celecoxib on Cartilage and in a Rat Osteoarthritis Model.
Abstract
The potential chondroprotective effect of celecoxib, a nonsteroidal anti-inflammatory drug and selective cyclooxygenase-2 inhibitor used to reduce pain and inflammation in knee osteoarthritis patients, is disputed. This study aimed at investigating the chondroprotective effects of celecoxib on (1) human articular cartilage explants and (2) in an osteoarthritis rat model.