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Papers of the Week


Papers: 6 Aug 2022 - 12 Aug 2022


Animal Studies


2022 Aug 05


Pharmacol Rep

Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity.

Authors

Zygmunt M, Ślusarczyk M, Jankowska A, Świerczek A, Bryła A, Mogilski S, Kazek G, Sapa J, Wyska E, Chłoń-Rzepa G
Pharmacol Rep. 2022 Aug 05.
PMID: 35930193.

Abstract

To verify the validity of the proposed pain treatment approach, which is based on concomitant blocking of the Transient Receptor Potential Ankyrin 1 (TRPA1) channel and phosphodiesterases (PDEs) 4B/7A activity, we continued our pharmacological studies on 8-alkoxypurine-2,6-diones selected based on previous in vitro screening.