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Papers of the Week


Papers: 30 Jul 2022 - 5 Aug 2022


Pharmacology/Drug Development


2022 Aug 04


Pain Ther

Immunoglobulin Use for the Management of Painful Peripheral Neuropathy: A Systematic Review and Meta-Analysis.

Authors

Zis P, Liampas A, Pozotou T, Parperis K, Artemiadis A, Hadjigeorgiou G
Pain Ther. 2022 Aug 04.
PMID: 35925489.

Abstract

Immunoglobulins (IG) are widely used for the treatment of a variety of immune-mediated diseases. The exact mechanism of action remains unknown, but IG modulate the expression and function of Fc receptors, interfere with complement activation and production of cytokines, neutralize pathogenic autoantibodies, and affect the activation and effector functions of B and T lymphocytes. Immunoglobulins are usually delivered intravenously, and are effective in ameliorating motor symptoms, and/or preventing disease progression in immune-mediated neuropathies, including Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.