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Papers: 11 Jun 2022 - 17 Jun 2022


2022 Jun 14


Mol Biol Rep

Inflammatory-associated apoptotic markers: are they the culprit to rheumatoid arthritis pain?

Authors

Khir N A M, Noh A' S M, Long I, Ismail N I, Siran R, Ismail C A N
Mol Biol Rep. 2022 Jun 14.
PMID: 35699858.

Abstract

Rheumatoid arthritis (RA) is a prolonged inflammatory disease resulting from autoimmune reactions that leads to local and systemic bone erosion, joint defects and functional impairment. Although the inflammation is subsided through the prescription of anti-inflammatory therapeutics, the patients persistently complained of sleepless nights due to flare pain. This indicates the possible contribution of other pathways besides inflammation in leading to RA pain. This review aims to uncover the roles and involvement of several inflammatory-associated apoptotic markers in facilitating pain transmission and processing during the pathogenesis of RA.