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Papers of the Week


Papers: 14 May 2022 - 20 May 2022


Human Studies


2022


Front Neurol


13

Sleep, Pain, and Neurodegeneration: A Mendelian Randomization Study.

Authors

Grover S, Sharma M
Front Neurol. 2022; 13:765321.
PMID: 35585838.

Abstract

Our aim was to determine whether the genetic liability to sleep and pain-related traits have a causal effect on risk of neurodegeneration in individuals of predominantly European ancestry. We selected five neurodegenerative disorders, namely, age-related macular degeneration (AMD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and Parkinson's disease (PD). Sleep duration (SD), short sleep (SS), long sleep (LS), chronotype (CHR), morning person (MP), insomnia (INS), and multisite chronic pain (MCP) were considered as exposures. We conducted Mendelian randomization (MR) using an inverse-variance weighted (IVW) method to compute causal effect estimates using latest available GWAS data sets. The MP phenotype was observed as the strongest risk factor for genetic liability to AMD (OR = 1.192; 95% CI 1.078, 1.318, = 0.0007). We observed suggestive evidence of risky effects of CHR on AMD ( = 0.0034), SS on AD ( = 0.0044), and INS on ALS ( = 0.0123). However, we failed to observe any role of pain. The results were robust on sensitivity analyses. Our study highlighted the role of MP as a risk factor for AMD.