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Papers of the Week


Papers: 16 Apr 2022 - 22 Apr 2022


Pharmacology/Drug Development


2022 Apr 19


Eur J Pain

Verbascoside administered intrathecally attenuates hyperalgesia via activating mu-opioid receptors in a rat chronic constriction injury model.

Abstract

Verbascoside, a representative phenylethanoid glycoside, is widely distributed in plants and has various activities beneficial for human health. Although systemically administered verbascoside has an antinociceptive effect, little is known about the site and mechanism of its activity. The aim of the present study was to determine whether verbascoside attenuates neuropathic pain in the spinal cord and which pain regulatory systems are involved.