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Papers: 2 Apr 2022 - 8 Apr 2022
PAIN TYPE:
Migraine/Headache
2022 Apr 05
J Headache Pain
23
1
Adenosine is a purinergic signaling molecule with a wide range of physiological functions including anti- and pronociceptive properties. Adenosine receptors are expressed in the trigeminovascular system, and adenosine receptor antagonist, caffeine, relieves migraine headache. We performed a systematic review of the literature of preclinical data addressing the role of adenosine in migraine pathophysiology.