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Papers of the Week


Papers: 26 Mar 2022 - 1 Apr 2022


2022 Mar 26


Clin Epigenetics


14


1

Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain.

Authors

Goodin BR, Overstreet DS, Penn TM, Bakshi R, Quinn TL, Sims A, Ptacek T, Jackson P, Long LD, Aroke EN
Clin Epigenetics. 2022 Mar 26; 14(1):45.
PMID: 35346352.

Abstract

The pathoanatomic cause of chronic low back pain (cLBP) cannot be identified for up to 90% of individuals. However, dysfunctional processing of endogenous nociceptive input, measured as conditioned pain modulation (CPM), has been associated with cLBP and may involve changes in neuronal gene expression. Epigenetic-induced changes such as DNA methylation (DNAm) have been associated with cLBP.