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Papers of the Week


Papers: 26 Mar 2022 - 1 Apr 2022

PAIN TYPE:
Migraine/Headache


2022 Mar 25


Cephalalgia

The headache and aura-inducing effects of sildenafil in patients with migraine with aura.

Authors

Butt JH, S Eddelien H, Kruuse C
Cephalalgia. 2022 Mar 25:3331024221088998.
PMID: 35332812.

Abstract

It has not been established if migraine headache and migraine aura share common pathophysiological mechanisms. Sildenafil, a phosphodiesterase-5 inhibitor, causes cGMP accumulation and provokes migraine-like headache in patients with migraine without aura. We investigated if sildenafil induced aura and migraine-like headache in patients with migraine with aura.