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Papers: 19 Feb 2022 - 25 Feb 2022
RESEARCH TYPE:
Psychology
Human Studies, Pharmacology/Drug Development
2022 Feb 21
Anesthesiology
Ketamine produces potent analgesia combined with psychedelic effects. It has been suggested that these two effects are associated and possibly that analgesia is generated by ketamine-induced dissociation. The authors performed a post hoc analysis of previously published data to quantify the pharmacodynamic properties of ketamine-induced antinociception and psychedelic symptoms. The hypothesis was that ketamine pharmacodynamics (i.e., concentration-effect relationship as well as effect onset and offset times) are not different for these two endpoints.