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Papers of the Week


Papers: 18 Dec 2021 - 24 Dec 2021


Pharmacology/Drug Development


2021 Dec 21


J Peripher Nerv Syst

Vitamin B6 Levels Do Not Correlate with Severity of Neuropathy in Chronic Idiopathic Axonal Polyneuropathy.

Authors

Stewart SL, Thomas S, Höke E, Simpson D, Singleton RJ, Höke A
J Peripher Nerv Syst. 2021 Dec 21.
PMID: 34931740.

Abstract

Pyridoxine (vitamin B6) toxicity is known to cause a length-dependent, sensory predominant axonal polyneuropathy. There is debate regarding the threshold at which intake levels can cause neurological symptoms through pyridoxine toxicity. We asked if elevated plasma vitamin B6 levels were related to outcome measures in a well-characterized cohort of patients with chronic idiopathic axonal polyneuropathy (CIAP).