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Papers of the Week
Methadone maintenance patients lack analgesic response to a cumulative intravenous dose of 32 mg of hydromorphone.
Abstract
Acute pain management in patients with opioid use disorder who are maintained on methadone presents unique challenges due to high levels of opioid tolerance in this population. This randomized controlled study assessed the analgesic and abuse liability effects of escalating doses of acute intravenous (IV) hydromorphone versus placebo utilizing a validated experimental pain paradigm, quantitative sensory testing (QST).