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Papers of the Week


Papers: 5 Jun 2021 - 11 Jun 2021


Animal Studies, Pharmacology/Drug Development


2021 Jul-Aug


Pain Rep


6


2

Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice.

Authors

Meloto CB, Ingelmo P, Perez E V, Pitt R, González Cárdenas V H, Mohamed N, Sotocinal SG, Bourassa V, Lima L V, Ribeiro-da-Silva A, Mogil JS, Diatchenko L
Pain Rep. 2021 Jul-Aug; 6(2):e902.
PMID: 34104835.

Abstract

Mast cell (MC) activation could establish a positive feedback loop that perpetuates inflammation and maintains pain. Stabilizing MCs with ketotifen fumarate (KF) may disrupt this loop and relieve pain.