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Papers of the Week


Papers: 8 May 2021 - 14 May 2021


Animal Studies, Pharmacology/Drug Development


2021


J Pain Res


14

Ulinastatin Exhibits Antinociception in Rat Models of Acute Somatic and Visceral Pain Through Inhibiting the Local and Central Inflammation.

Authors

Zhan M-X, Tang L, Lu Y-F, Wu H-H, Guo Z-B, Shi Z-M, Yang C-L, Zou Y-Q, Yang F, Chen G-Z
J Pain Res. 2021; 14:1201-1214.
PMID: 33976570.

Abstract

Ulinastatin, a broad-spectrum serine protease inhibitor, has been widely used to treat various diseases clinically. However, so far, the antinociceptive effect of ulinastatin remains less studied experimentally and the underlying mechanisms of ulinastatin for pain relief remain unclear. This study aimed to find evidence of the analgesic effect of ulinastatin on acute somatic and visceral pain.