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Papers of the Week
Locus revealed: Painlessness via loss of Na1.7 at central terminals of sensory neurons.
Authors
Abstract
How genetic loss of the sodium channel Na1.7 results in painlessness is puzzling. MacDonald et al. (2021) demonstrate that instead of impairing peripheral excitability, Na1.7 channels at central terminals of pain-sensing afferents play a pivotal role in the balance between pain and analgesia.