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Papers of the Week


Papers: 3 Apr 2021 - 9 Apr 2021


Animal Studies

PAIN TYPE:
Itch


2021 Apr 02


Gastroenterology

Epithelia-sensory neuron crosstalk underlies cholestatic itch induced by lysophosphatidylcholine.

Authors

Chen Y, Wang Z-L, Yeo M, Zhang Q-J, López-Romero AE, Ding H-P, Zhang X, Zeng Q, Morales-Lázaro SL, Moore C, Jin Y-A, Yang H-H, Morstein J, Bortsov A, Krawczyk M, Lammert F, Abdelmalek M, Diehl A M, Milkiewicz P, Kremer AE, et al.
Gastroenterology. 2021 Apr 02.
PMID: 33819485.

Abstract

Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of anti-pruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus.