I am a
Home I AM A Search Login

Papers of the Week


Papers: 27 Mar 2021 - 2 Apr 2021


Animal Studies


2021 Jan-Dec


Mol Pain


17

SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury.

Authors

Tsymbalyuk O, Gerzanich V, Mumtaz A, Andhavarapu S, Ivanova S, Makar TK, Sansur CA, Keller A, Nakamura Y, Bryan J, Simard MJ
Mol Pain. 2021 Jan-Dec; 17:17448069211006603.
PMID: 33788643.

Abstract

Neuropathic pain following peripheral nerve injury (PNI) is linked to neuroinflammation in the spinal cord marked by astrocyte activation and upregulation of interleukin 6 (IL6 chemokine (C-C motif) ligand 2 (CCL2) and chemokine (C-X-C motif) ligand 1 (CXCL1), with inhibition of each individually being beneficial in pain models.