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Papers of the Week


Papers: 20 Mar 2021 - 26 Mar 2021


Animal Studies


2021 Mar 23


J Neuroinflammation


18


1

Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity.

Authors

Dansereau M-A, Midavaine É, Bégin-Lavallée V, Belkouch M, Beaudet N, Longpré J-M, Mélik-Parsadaniantz S, Sarret P
J Neuroinflammation. 2021 Mar 23; 18(1):79.
PMID: 33757529.

Abstract

Pain is reported as the leading cause of disability in the common forms of inflammatory arthritis conditions. Acting as a key player in nociceptive processing, neuroinflammation, and neuron-glia communication, the chemokine CCL2/CCR2 axis holds great promise for controlling chronic painful arthritis. Here, we investigated how the CCL2/CCR2 system in the dorsal root ganglion (DRG) contributes to the peripheral inflammatory pain sensitization.