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Papers of the Week


Papers: 20 Mar 2021 - 26 Mar 2021


Pharmacology/Drug Development


2021 Mar


Pain Physician


24


2

Receptor and Molecular Targets for the Development of Novel Opioid and Non-Opioid Analgesic Therapies.

Authors

Chen R, Coppes MOJ, Urman RD
Pain Physician. 2021 Mar; 24(2):153-163.
PMID: 33740349.

Abstract

Although conventional pain relief therapeutics have centered around mu-opioid agonists, these drugs are limited by adverse side effects, including respiratory depression and addiction potential. The ongoing opioid epidemic has galvanized research into novel analgesic therapies with more favorable profiles. New pharmacologic agents have been developed to target neuronal pathways involved in pain sensation. Certain receptors have been recognized to mediate nociceptive transmission, central sensitization, and the development of chronic pain states.