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Papers of the Week


Papers: 13 Mar 2021 - 19 Mar 2021


Animal Studies


2021 Mar 07


World J Gastroenterol


27


9

Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry.

Authors

McIlwrath SL, Starr ME, High AE, Saito H, Westlund KN
World J Gastroenterol. 2021 Mar 07; 27(9):794-814.
PMID: 33727771.

Abstract

Acute pancreatitis (AP) and recurring AP are serious health care problems causing excruciating pain and potentially lethal outcomes due to sepsis. The validated caerulein- (CAE) induced mouse model of acute/recurring AP produces secondary persistent hypersensitivity and anxiety-like behavioral changes for study.