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Papers: 6 Mar 2021 - 12 Mar 2021


2021 Mar 04


Br J Anaesth

Minimal clinically important differences in randomised clinical trials on pain management after total hip and knee arthroplasty: a systematic review.

Authors

Abstract

Sample size determination is essential for reliable hypothesis testing in clinical trials and should rely on adequate sample size calculations with alpha, beta, variance, and an effect size being the minimal clinically important difference (MCID). This facilitates interpretation of the clinical relevance of statistically significant results. No gold standard for MCIDs exists in postoperative pain research.