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Papers of the Week


Papers: 6 Mar 2021 - 12 Mar 2021


Animal Studies


2021 Feb 25


J Neuroimmunol


354

Are sensory neurons exquisitely sensitive to interleukin 1β?

Authors

Stemkowski PL, Bukhanova-Schulz N, Baldwin T, de Chaves E P, Smith PA
J Neuroimmunol. 2021 Feb 25; 354:577529.
PMID: 33676084.

Abstract

Peripheral nerve injury frequently evokes chronic neuropathic pain. This is initiated by a transient inflammatory response that leads to persistent excitation of dorsal root ganglion (DRG) neurons by inflammatory cytokines such as interleukin 1β(IL-1β). In non-neuronal cells such as lymphocytes, interleukin 1 exerts actions at attomolar (aM; 10 M) concentrations. We now report that DRG neurons in defined-medium, neuron-enriched culture display increased excitability following 5-6 d exposure of 1aM IL-1β. This response is mediated in part by type 1 interleukin receptors and involves decreased function of putative K1.1 channels. This finding provides new insights into the neuroimmune interactions responsible for neuropathic pain.