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Papers of the Week


Papers: 20 Feb 2021 - 26 Feb 2021


Animal Studies, Pharmacology/Drug Development


2021 Feb 13


Drug Alcohol Depend


221

Repeated morphine exposure activates synaptogenesis and other neuroplasticity-related gene networks in the dorsomedial prefrontal cortex of male and female rats.

Authors

Liu SX, Gades MS, Swain Y, Ramakrishnan A, Harris AC, Tran PV, Gewirtz JC
Drug Alcohol Depend. 2021 Feb 13; 221:108598.
PMID: 33626484.

Abstract

Opioid abuse is a chronic disorder likely involving stable neuroplastic modifications. While a number of molecules contributing to these changes have been identified, the broader spectrum of genes and gene networks that are affected by repeated opioid administration remain understudied.