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Papers of the Week
TRESK background potassium channel modifies the TRPV1-mediated nociceptor excitability in sensory neurons.
Abstract
TWIK-related spinal cord potassium channel (TRESK) background potassium channels have a key role in controlling resting membrane potential and excitability of sensory neurons. A frameshift mutation leading to complete loss of TRESK function has been identified in members of a family suffering from migraine with aura. In the present study, we examined the role of TRESK channels on nociceptor function in mice.