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Papers of the Week


Papers: 26 Dec 2020 - 1 Jan 2021


Animal Studies

PAIN TYPE:
Itch


2020 Dec 21


J Allergy Clin Immunol

Tick peptides evoke itch by activating MrgprC11/X1 to sensitize TRPV1 in pruriceptors.

Authors

Li X, Yang H, Han Y, Yin S, Shen B, Wu Y, Li W, Cao Z
J Allergy Clin Immunol. 2020 Dec 21.
PMID: 33358893.

Abstract

Tick bites severely threaten human health because they allow the transmission of many deadly pathogens, including viruses, bacteria, protozoa and helminths. Pruritus is a leading symptom of tick bites, but its molecular and neural bases remain elusive.