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Papers of the Week
Activation of Trace Amine-Associated Receptor 1 Selectively Attenuates the Reinforcing Effects of Morphine.
Abstract
Trace amine-associated receptor 1 (TAAR1) plays a critical role in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of TAAR1 modulates addiction-like behaviors associated with psychostimulants. However, little is known about whether TAAR1 modulation would regulate the behavioral effects of opioids.