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Papers of the Week


Papers: 28 Nov 2020 - 4 Dec 2020


Human Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2020 Nov 24


Lancet Neurol

Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial.

Authors

Obermann M, Nägel S, Ose C, Sonuc N, Scherag A, Storch P, Gaul C, Böger A, Kraya T, Jansen J-P, Straube A, Freilinger T, Kaube H, Jürgens TP, Diener H-C, Katsarava Z, Kleinschnitz C, Holle D
Lancet Neurol. 2020 Nov 24.
PMID: 33245858.

Abstract

Prednisone is commonly used for initial short-term therapy of episodic cluster headaches before preventive medication such as verapamil becomes effective, but this strategy has not been tested in large randomised trials. We aimed to access the safety and efficacy of this treatment approach.