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Papers of the Week


Papers: 21 Nov 2020 - 27 Nov 2020


Animal Studies


2020


J Pain Res


13

Intraneural Application of microRNA-1 Mimetic Nucleotides Does Not Resolve Neuropathic Pain After Chronic Constriction Injury in Rats.

Authors

Kuebart A, Wollborn V, Huhn R, Hermanns H, Werdehausen R, Brandenburger T
J Pain Res. 2020; 13:2907-2914.
PMID: 33223847.

Abstract

Alterations of the expression of microRNAs (miRNAs) in chronic pain models seem to play a crucial role in the development of neuropathic pain, with microRNA-1 (miR-1) being of particular interest. Recently, we were able to show that decreased miR-1 levels were associated with increased expression of brain-derived neurotrophic factor (BDNF) and Connexin 43 (Cx43). We hypothesized that miR-1 mimetic nucleotides could alleviate neuropathic pain caused by chronic constriction injury in rats.