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Papers of the Week


Papers: 14 Nov 2020 - 20 Nov 2020


Animal Studies

PAIN TYPE:
Migraine/Headache


2020 Nov 17


Cephalalgia

De novo protein synthesis is necessary for priming in preclinical models of migraine.

Authors

Lackovic J, Price TJ, Dussor G
Cephalalgia. 2020 Nov 17:333102420970514.
PMID: 33200943.

Abstract

Migraine attacks are often triggered by normally innocuous stimuli, suggesting that sensitization within the nervous system is present. One mechanism that may contribute to neuronal sensitization in this context is translation regulation of new protein synthesis. The goal of this study was to determine whether protein synthesis contributes to behavioral responses and priming in preclinical models of migraine.