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Papers of the Week


Papers: 14 Nov 2020 - 20 Nov 2020


Animal Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2020 Nov 17


Cephalalgia

Combined onabotulinumtoxinA/atogepant treatment blocks activation/sensitization of high-threshold and wide-dynamic range neurons.

Authors

Melo-Carrillo A, Strassman AM, Schain AJ, Adams A M, Brin MF, Burstein R
Cephalalgia. 2020 Nov 17:333102420970507.
PMID: 33200944.

Abstract

OnabotulinumtoxinA and agents that block calcitonin gene‒receptor peptide action have both been found to have anti-migraine effects, but they inhibit different populations of meningeal nociceptors. We therefore tested the effects of combined treatment with onabotulinumtoxinA and the calcitonin gene‒receptor peptide antagonist atogepant on activation/sensitization of trigeminovascular neurons by cortical spreading depression.