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Papers of the Week


Papers: 7 Nov 2020 - 13 Nov 2020


Animal Studies


2020 Nov 06


Neuron

Editor's Pick

Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury.

Authors

Peirs C, Williams S-PG, Zhao X, Arokiaraj CM, Ferreira DW, Noh M-C, Smith KM, Halder P, Corrigan KA, Gedeon JY, Lee S J, Gatto G, Chi D, Ross SE, Goulding M, Seal RP
Neuron. 2020 Nov 06.
PMID: 33181066.

Abstract

The spinal dorsal horn is a major site for the induction and maintenance of mechanical allodynia, but the circuitry that underlies this clinically important form of pain remains unclear. The studies presented here provide strong evidence that the neural circuits conveying mechanical allodynia in the dorsal horn differ by the nature of the injury. Calretinin (CR) neurons in lamina II inner convey mechanical allodynia induced by inflammatory injuries, while protein kinase C gamma (PKCγ) neurons at the lamina II/III border convey mechanical allodynia induced by neuropathic injuries. Cholecystokinin (CCK) neurons located deeper within the dorsal horn (laminae III-IV) are important for both types of injuries. Interestingly, the Maf subset of CCK neurons is composed of transient vesicular glutamate transporter 3 (tVGLUT3) neurons, which convey primarily dynamic allodynia. Identification of an etiology-based circuitry for mechanical allodynia in the dorsal horn has important implications for the mechanistic and clinical understanding of this condition.